High Intensity Focused Ultrasound Optimal Device Design for Targeted Prostate Cancer Treatment: A Numerical Study

DOI: 10.4236/jmp.2013.42034   PDF   HTML   XML   3,718 Downloads   6,270 Views   Citations


A parametric study was performed to design a device capable of treating small targeted regions within the prostate using high intensity focused ultrasound, while sparing the surrounding organs and minimizing the number of elements. The optimal focal length (L), operating frequency (f), element size (a) and central opening radius for lodging an imaging probe (r) of a device that would safely treat tissue within the prostate were obtained. Images from the Visible Human Project were used to determine simulated organ sizes and treatment locations. Elliptical tumors were placed throughout the simulated prostate and their lateral and axial limits were selected as test locations. Using graphics processors, the acoustic field and Bio-Heat Transfer Equation were solved to calculate the heating produced during a simulated treatment. L, f, a and r were varied from 45 to 75 mm, 2.25 to 3 MHz, 1.5 to 8 times the wavelength and 9 to 12.5 mm, respectively. The resulting optimal device was a 761-element concentric-ring transducer with L = 68 mm, f = 2.75 MHz, a = 2.05λ and r = 9 mm. Simulated thermal lesions showed that it was possible to treat target tumors consistent with reported locations and sizes for prostate cancer.

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L. Curiel, D. Hobson, J. Chapelon and S. Pichardo, "High Intensity Focused Ultrasound Optimal Device Design for Targeted Prostate Cancer Treatment: A Numerical Study," Journal of Modern Physics, Vol. 4 No. 2, 2013, pp. 240-245. doi: 10.4236/jmp.2013.42034.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S. Crouzet, X. Rebillard, D. Chevallier, et al., “Multicentric Oncologic Outcomes of High-Intensity Focused Ultrasound for Localized Prostate Cancer in 803 Patients,” European Urology, Vol. 58, No. 4, 2010, pp. 559-566. doi:10.1016/j.eururo.2010.06.037
[2] T. Uchida, H. Ohkusa, H. Yamashita, et al., “Five Years Experience of Transrectal High-Intensity Focused Ultrasound Using the Sonablate Device in the Treatment of Localized Prostate Cancer,” International Journal of Urology, Vol. 13, No. 3, 2006, pp. 228-233. doi:10.1111/j.1442-2042.2006.01272.x
[3] L. Poissonnier, J. Y. Chapelon, O. Rouviere, et al., “Control of Prostate Cancer by Transrectal HIFU in 227 Patients,” European Urology, Vol. 51, No. 2, 2007, pp. 381-387. doi:10.1016/j.eururo.2006.04.012
[4] C. Netsch, T. Bach, E. Gross and A. J. Gross, “Rectourethral Fistula after High-Intensity Focused Ultrasound Therapy for Prostate Cancer and Its Surgical Management,” Urology, Vol. 77, No. 4, 2011, pp. 999-1004. doi:10.1016/j.urology.2010.10.028
[5] A. Blana, S. Rogenhofer, R. Ganzer, et al., “Eight Years’ Experience with High-Intensity Focused Ultrasonography for Treatment of Localized Prostate Cancer,” Urology, Vol. 72, No. 6, 2008, pp. 1329-1333. doi:10.1016/j.urology.2008.06.062
[6] F. J. Murat, L. Poissonnier, M. Rabilloud, et al., “Midterm Results Demonstrate Salvage High-Intensity Focused Ultrasound (HIFU) as an Effective and Acceptably Morbid Salvage Treatment Option for Locally Radiorecurrent Prostate Cancer,” European Urology, Vol. 55, No. 3, 2008, pp. 640-649. doi:10.1016/j.eururo.2008.04.091
[7] S. Pichardo, A. Gelet, L. Curiel, S. Chesnais and J. Y. Chapelon, “New Integrated Imaging High Intensity Focused Ultrasound Probe for Transrectal Prostate Cancer Treatment,” Ultrasound in Medicine and Biology, Vol. 34, No. 7, 2008, pp. 1105-1116. doi:10.1016/j.ultrasmedbio.2007.12.005
[8] L. Curiel, F. Chavrier, B. Gignoux, S. Pichardo, S. Chesnais and J. Y. Chapelon, “Experimental Evaluation of Lesion Prediction Modelling in the Presence of Cavitation Bubbles: Intended for High-Intensity Focused Ultrasound Prostate Treatment,” Medical and Biological Engineering and Computing, Vol. 42, No. 1, 2004, pp. 44-54. doi:10.1007/BF02351010
[9] G. S. Chen, C. Y. Lin, J. S. Jeong, et al., “Design and Characterization of Dual-Curvature 1.5-Dimensional High-Intensity Focused Ultrasound Phased-Array Transducer,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 59, No. 1, 2012, pp. 150-155. doi:10.1109/TUFFC.2012.2166
[10] D. Pajek and K. Hynynen, “The Design of a Focused Ultrasound Transducer Array for the Treatment of Stroke: A Simulation Study,” Physics in Medicine and Biology, Vol. 57, No. 15, 2012, pp. 4951-4968. doi:10.1088/0031-9155/57/15/4951
[11] S. Pichardo and K. Hynynen, “New Design for an Endoesophageal Sector-Based Array for the Treatment of Atrial Fibrillation: A Parametric Simulation Study,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 56, No. 3, 2009, pp. 600-612. doi:10.1109/TUFFC.2009.1076
[12] E. P. F. de Lausanne, “Visible Human Server,” 2012. http://visiblehuman.epfl.ch/
[13] X. Fan and K. Hynynen, “The Effect of Wave Reflection and Refraction at Soft Tissue Interfaces during Ultrasound Hyperthermia Treatments,” Journal of the Acoustical Society of America, Vol. 91, No. 3, 1992, pp. 1727- 1736. doi:10.1121/1.402452
[14] R. Cobbold, “Foundations of Biomedical Ultrasound,” Oxford University Press, Oxford, 2007.
[15] H. H. Pennes, “Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm,” Journal of Applied Physiology, Vol. 85, No. 1, 1998, pp. 5-34.
[16] S. A. Sapareto and W. C. Dewey, “Thermal Dose Determination in Cancer Therapy,” International Journal of Radiation Oncology, Vol. 10, No. 6, 1984, pp. 787-800. doi:10.1016/0360-3016(84)90379-1
[17] F. V. Coakley, J. Kurhanewicz, Y. Lu, et al., “Prostate Cancer Tumor Volume: Measurement with Endorectal MR and MR Spectroscopic Imaging,” Radiology, Vol. 223, No. 1, 2002, pp. 91-97. doi:10.1148/radiol.2231010575
[18] X. Yin, L. M. Epstein and K. Hynynen, “Noninvasive Trans-Esophageal Cardiac Thermal Ablation Using a 2-D Focused, Ultrasound Phased Array: A Simulation Study,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 53, No. 6, 2006, pp. 1138-1149. doi:10.1109/TUFFC.2006.1642512
[19] S. Pichardo and K. Hynynen, “Circumferential Lesion Formation around the Pulmonary Veins in the Left Atrium with Focused Ultrasound Using a 2D-Array Endoesophageal Device: A Numerical Study,” Physics in Medicine and Biology, Vol. 52, No. 16, 2007, pp. 4923-4942. doi:10.1088/0031-9155/52/16/014
[20] C. Damianou and K. Hynynen, “The Effect of Various Physical Parameters on the Size and Shape of Necrosed Tissue Volume during Ultrasound Surgery,” Journal of the Acoustical Society of America, Vol. 95, No. 3, 1994, pp. 1641-1649. doi:10.1121/1.408550
[21] S. D. C. Walsh, M. O. Saar, P. Bailey and D. J. Lilja, “Accelerating Geoscience and Engineering System Simulations on Graphics Hardware,” Computers and Geosciences, Vol. 35, No. 12, 2009, pp. 2353-2364. doi:10.1016/j.cageo.2009.05.001

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