Calcium Affects on Vascular Endpoints (CAVE) Retrospective Cohort Trial

DOI: 10.4236/ojemd.2013.31012   PDF   HTML   XML   3,064 Downloads   5,326 Views  

Abstract

Purpose The goal of this study was to examine the association of calcium supplements with coronary artery disease and survival. Our initial hypothesis was that when adjusted for risk factors, calcium supplements would not affect overall survival outcomes or coronary artery disease prevalence in a community population followed by a large cardiovascular practice. Methods Data was retrospectively collected for 5 years and 8 months (1/1/2004to 10/8/2009) from the electronic medical record at a large cardiovascular practice at a university. Only patients ≥ age 50 were included in our analysis Results The baseline characteristics of the 8060 study subjects. For the entire study population the mean age was 65 +/– 10 years, 71% were women. On multivariable logistic regression analysis, calcium supplementation was not an independent predictor of all-cause death, nor was calcium supplementation an independent predictor of the diagnosis of coronary artery disease. Survival analysis showed no survival differences for patients on calcium supplements (p = NS). Hazard ratios using the Cox proportional hazards model were calculated, showing that calcium supplementation was not an independent predictor of reduced survival. Conclusion This study suggests that there was no association between calcium supplementation and coronary artery disease as well as overall survival in a large retrospective cohort of patients greater than 50 with high rates of significant cardiovascular risk factors.

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R. K. Bhattacharya, V. B. Patel and J. L. Vacek, "Calcium Affects on Vascular Endpoints (CAVE) Retrospective Cohort Trial," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 1, 2013, pp. 75-79. doi: 10.4236/ojemd.2013.31012.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] R. P. Heaney, “The Calcium Controversy: Finding a Middle Ground between the Extremes,” Public Health Reports, Vol. 104, 1989, pp. 36-46.
[2] C. C. Jr. Johnston, J. Z. Miller, C. W. Slemenda, et al., “Calcium Supplementation and Increases in Bone Mineral Density in Children,” The New England Journal of Medicine, Vol. 327, No. 2, 1992, pp. 82-87. doi:10.1056/NEJM199207093270204
[3] P. J. Elders, P. Lips, J. C. Netelenbos, et al., “Long-Term Effect of Calcium Supplementation on Bone Loss in Perimenopausal Women,” Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, Vol. 9, No. 7, 1994, pp. 963-970.
[4] B. M. Tang, G. D. Eslick, C. Nowson, et al., “Use of Calcium or Calcium in Combination with Vitamin D Supplementation to Prevent Fractures and Bone Loss in People Aged 50 Years and Older: A Meta-Analysis,” The Lancet, Vol. 370, No. 9588, 2007, pp. 657-666. doi:10.1016/S0140-6736(07)61342-7
[5] M. J. Bolland, P. A. Barber, R. N. Doughty, et al., “Vascular Events in Healthy Older Women Receiving Calcium Supplementation: Randomised Controlled Trial,” BMJ, Vol. 336, No. 7638, 2008, pp. 262-266. doi:10.1136/bmj.39440.525752.BE
[6] M. J. Bolland, A. Avenell, J. A. Baron, et al., “Effect of Calcium Supplements on Risk of Myocardial Infarction and Cardiovascular Events: Meta-Analysis,” BMJ, Vol. 341, 2010, p. c3691. doi:10.1136/bmj.c3691
[7] J. Hsia, G. Heiss, H. Ren, et al., “Calcium/Vitamin D Supplementation and Cardiovascular Events,” Circulation, Vol. 115, No. 7, 2007, pp. 846-854. doi:10.1161/CIRCULATIONAHA.106.673491
[8] J. E. Manson, M. A. Allison, J. J. Carr, et al., “Calcium/ Vitamin D Supplementation and Coronary Artery Calcification in the Women’s Health Initiative,” Menopause, Vol. 17, No. 4, 2010, pp. 683-691.
[9] I. R. Reid, R. W. Ames, M. C. Evans, et al., “Effect of Calcium Supplementation on Bone Loss in Postmenopausal Women,” The New England Journal of Medicine, Vol. 328, No. 7, 1993, pp. 460-464. doi:10.1056/NEJM199302183280702
[10] A. M. Grant, A. Avenell, M. K. Campbell, et al., “Oral Vitamin D3 and Calcium for Secondary Prevention of Low-Trauma Fractures in Elderly People (Randomised Evaluation of Calcium or Vitamin D, RECORD): A Randomised Placebo-Controlled Trial,” The Lancet, Vol. 365, No. 9471, 2005, pp. 1621-1628. doi:10.1016/S0140-6736(05)63013-9
[11] I. R. Reid, B. Mason, A. Horne, et al., “Randomized Controlled Trial of Calcium in Healthy Older Women,” The American Journal of Medicine, Vol. 119, No. 9, 2006, pp. 777-785. doi:10.1016/j.amjmed.2006.02.038
[12] B. Dawson-Hughes, G. E. Dallal, E. A. Krall, et al., “A Controlled Trial of the Effect of Calcium Supplementation on Bone Density in Postmenopausal Women,” The New England Journal of Medicine, Vol. 323, No. 13, 1990, pp. 878-883. doi:10.1056/NEJM199009273231305
[13] B. L. Riggs, W. M. O'Fallon, J. Muhs, et al., “Long-Term Effects of Calcium Supplementation on Serum Parathyroid Hormone Level, Bone Turnover, and Bone Loss in Elderly Women,” Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, Vol. 13, No. 2, 1998, pp. 168-174.
[14] R. L. Prince, A. Devine, S. S. Dhaliwal and I. M. Dick, “Effects of Calcium Supplementation on Clinical Fracture and Bone Structure: Results of a 5-Year, Double-Blind, Placebo-Controlled Trial in Elderly Women,” Archives of Internal Medicine, Vol. 166, No. 8, 2006, pp. 869-875.
[15] S. Bonnick, S. Broy, F. Kaiser, et al., “Treatment with Alendronate Plus Calcium, Alendronate Alone, or Calcium Alone for Postmenopausal Low Bone Mineral Density,” Current Medical Research and Opinion, Vol. 23, No. 6, 2007, pp. 1341-1349. doi:10.1185/030079907X188035
[16] J. M. Lappe, D. Travers-Gustafson, K. M. Davies, et al., “Vitamin D and Calcium Supplementation Reduces Cancer Risk: Results of a Randomized Trial,” The American Journal of Clinical Nutrition, Vol. 85, No. 6, 2007, pp. 1586-1591.
[17] R. M. Bostick, L. H. Kushi, Y. Wu, et al., “Relation of Calcium, Vitamin D, and Dairy Food Intake to Ischemic Heart Disease Mortality among Postmenopausal Women,” American Journal of Epidemiology, Vol. 149, No. 2, 1999, pp. 151-161. doi:10.1093/oxfordjournals.aje.a009781
[18] J. R. Lewis, J. Calver, K. Zhu, et al., “Calcium Supplementation and the Risks of Atherosclerotic Vascular Disease in Older Women: Results of a 5-Year RCT and a 4.5-Year Follow-Up,” Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, Vol. 26, No. 1, 2011, pp. 35-41.

  
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