Functioning Adrenocortical Oncocytic Carsinoma: A Case Report

DOI: 10.4236/ojemd.2013.31006   PDF   HTML   XML   3,925 Downloads   6,370 Views   Citations

Abstract

Introduction: Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually nonfunctioning. Only a little more than fifty cases have been described in the literature. Case Presentation: We report the case of an adrenocortical oncocytic neoplasm with malignant potential in a 21-year-old female with co-secrete testosterone and cortisol. The patient had been operated of adrenal mass. Fallowing operation, the Cushing’s syndrome and high testosterone levels resolved. Conclusion: In our knowledge this is the first case in the l?terature which co-secret cortizol and testosterone in malign oncystoma.

Share and Cite:

M. Atmaca, S. Yıldız, I. Kalan, M. Fatih Özbay, D. Yılmaz, M. Kara Tanrıtanır and M. Öztürk, "Functioning Adrenocortical Oncocytic Carsinoma: A Case Report," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 1, 2013, pp. 42-45. doi: 10.4236/ojemd.2013.31006.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] H. Hamperl, “Onkocytes and the so Called Hurthle Cell Tumor,” Archives of Pathology, Vol. 49, 1950, pp. 563-570.
[2] A. Chang and S. J. Harawi, “Oncocytes, Oncytosis and Oncytotic Tumors,” Pathology Annual, Vol. 27, No. 1, 1992, pp. 263-304.
[3] S. Kakimoto, Y. Yushita, T. Sanefugi, A. Kondo, N. Fujishima, M. Kishikawa, et al., “Non-Hormonal Adrenocortical Ademona with Oncocytoma Like Appearances,” Hinyokika Kiyo. Acta Urologica Japonica, Vol. 32, No. 5, 1986, pp. 757-763.
[4] X. J. Tian,Y. Huang, J. Lu and L. L. Ma, “Laparoscopic Adrenocortical Oncocytoma Resection,” Chinese Medical Journal, Vol. 121, No. 9, 2008, pp. 862-864.
[5] Z. W. Baloch and V. A. LiVolsi, “Oncocytic Lesions of the Neuroendocrine System,” Seminars in Diagnostic Pathology, Vol. 16, No. 2, 1999, pp. 190-199.
[6] B. T. Lin, S. M. Bonsib, G. W. Mierau, L. M. Weiss and L. J. Medeiros, “Oncocytic Adrenal Neoplasms: A Report of Seven Cases and Review of the Literature,” The American Journal of Surgical Pathology, Vol. 22, No. 5, 1998, pp. 603-614. doi:10.1097/00000478-199805000-00012
[7] D. Botsios, K. Blouhos, K. Vasiliadis, A. Asimaki, K. Tsalis and D. Betsis, “Adrenocortical Oncocytoma: A Rare Tumor of Undefined Malignant Potential,” Surgery Today, Vol. 37, No. 7, 2007, pp. 612-617. doi:10.1007/s00595-006-3458-4
[8] G. Mikuz, “Clinical Pathology of Urologic Tumors,” CRC Press, Boca Raton, 2007.
[9] M. N. Morra and S. Das, “Renal Oncocytoma: A Review of Histogenesis, Histopathology, Diagnosis and Treatment,” Journal of Urology, Vol. 150, No. 2, 1993, pp. 295-302.
[10] G. K. Nguyen, R. Vriend, D. Ronagham and W. H. Lakey, “Heterotopic Adrenocortical Oncocytoma: A Case Report with Light and Electron Microscopic Studies,” Cancer, Vol. 70, No. 11, 1992, pp. 2681-2684. doi:10.1002/1097-0142(19921201)70:11<2681::AID-CNCR2820701119>3.0.CO;2-H
[11] J. R. Goldblum, R. Shannon, E. P. Kaldjian, M. Thiny, R. Davenport, N. Thompson and R. V. Lloyd, “Immunohistochemical Assessment of Proliferative Activity in Adrenocortical Neoplasms,” Modern Pathology, Vol. 6, No. 6, 1993, pp. 663-668.
[12] M. P. Vargas, H. I. Vargas, D. E. Kleiner and M. J. Merino, “Adrenocortical Neoplasms: Role of Prognostic Markers MIB-1, P53 and RB,” The American Journal of Surgical Pathology, Vol. 21, No. 5, 1997, pp. 556-562. doi:10.1097/00000478-199705000-00008
[13] J. S. Winston, A. Mompoint, H. Wang and D. Crossland, “The Utility of Ki-67 in the Evaluation of Adrenocortical Neoplasms,” Modern Pathology, Vol. 10, 1997, p. 52A.
[14] M. Bisceglia, O. Ludovico, A. Di Mattia, D. Ben-Dor, J. Sandbank, G. Pasquinelli, S. K. Lau and L. M. Weiss, “Adrenocortical Oncocytic Tumors: Report of 10 Cases and Review of the Literature,” International Journal of Surgical Pathology, Vol. 12, No. 3, 2004, pp. 231-243. doi:10.1177/106689690401200304
[15] S. Krishnamurthy, N. G. Ordonez, T. O. Shelton, A. G. Ayala and N. Sneige, “Fine-Needle Aspiration Cytology of a Case of Oncocytic Adrenocortical Carcinoma,” Diagnostic Cytopathology, Vol. 22, No. 5, 2000, pp. 299-303. doi:10.1002/(SICI)1097-0339(200005)22:5<299::AID-DC8>3.0.CO;2-5
[16] M. P. Hoang, A. G. Ayala and J. Albores-Saavedra, “Oncocytic Adrenocortical Carcinoma: A Morphologic, Immunohistochemical and Ultrastructural Study of Four Cases,” Modern Pathology, Vol. 15, No. 9, 2002, pp. 973-978. doi:10.1038/modpathol.3880638
[17] A. K. El-Naggar, D. B. Evans and B. Mackay, “Oncocytic Adrenal Cortical Carcinoma,” Ultrastructural Pathology, Vol. 15, No. 4-5, 1991, pp. 549-556. doi:10.3109/01913129109016262
[18] R. Kurek, R. Von Knobloch, U. Feek, A. Heidenreich and R. Hofmann, “Local Recurrence of an Oncocytic Adrenocortical Carcinoma with Ovary Metastasis,” Journal of Urology, Vol. 166, No. 3, 2001, p. 985. doi:10.1016/S0022-5347(05)65882-X
[19] F. Go?kowski, M. Buziak-Bereza, B, Huszno, A. Ba?dys-Waligórska, A. Stefańska, A. Budzyński, K. Okoń, R. Chrzan and A. Urbanik, “The Unique Case of Adrenocortical Malignant and Functioning Oncocytic Tumour,” Experimental and Clinical Endocrinology & Diabetes, Vol. 115 No. 6, 2007 pp. 401-404. doi:10.1055/s-2007-967083
[20] L. M. Weiss, L. J. Medeiros and A. L. Vickery Jr., “Pathologic Features of Prognostic Significance in Adrenocortical Carcinoma,” The American Journal of Surgical Pathology, Vol. 13, No. 3, 1989, pp. 202-206. doi:10.1097/00000478-198903000-00004
[21] E. J. Gandras, L. H. Schwartz, D. M. Panicek and G. Levi, “Case Report. Adrenocortical Oncocytoma: CT and MRI Findings,” Journal of Computer Assisted Tomography, Vol. 20, No. 3, 1996, pp. 407-409. doi:10.1097/00004728-199605000-00016
[22] D. J. Kim, J. J. Chung, Y. H. Ryu, S. W. Hong, J. S. Yu, and J. H. Kim, “Adrenocortical Oncocytoma Displaying Intense Activity on 18F-FDG-PET: A Case Report and a Literature Review,” Annals of Nuclear Medicine, Vol. 22 No. 9, 2008, pp. 821-824. doi:10.1007/s12149-008-0199-z
[23] B. Allolio and M. Fassnacht, “Clinical Review: Adrenocortical Carcinoma: Clinical Update,” The Journal of Clinical Endocrinology & Metabolism, Vol. 91, No. 6, 2006, pp. 2027-2037. doi:10.1210/jc.2005-2639
[24] C. I. M. van Ditzhuijsen, R. van de Weijer and H. R. Haak, “Adrenocortical Carcinoma,” Netherlands Journal of Medicine, Vol. 65, No. 2, 2007, pp. 55-60.

  
comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.