The Correlation of Lung Function Indexes and Survival Time of Patients with Advanced Lung Cancer

Wenjing Xu, Zhenghua Jiang, Dongyun Huang, Muyun Zhu, Qian Huang, Hui Ge, Juan Liu, Yan Qin

Department of Geriatric Medicine, Subei People’s Hospital, Yangzhou, China.
Department of Pulmonary Medicine, Subei People’s Hospital, Yangzhou, China.

DOI: 10.4236/jct.2013.41029                

Abstract

Background: To those patients with advanced lung cancer, the ultimate objective is to improve the quality of life, and lung function is an important factor affecting quality of life. We detect lung function of patients with lung cancer and study the correlation between lung function and the patients’ survival time, to provide reference for evaluation of disease progression and prognosis. Methods: Lung function was detected on 59 cases of lung cancer and 63 normal controls. The relationship between lung function indexes and survival time was analyzed. Results: There was significant difference in ventilation function and diffusing capacity between lung cancer group and control group. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV) were positively correlated to survival time in patients with advanced lung cancer (r = 0.28522064, 0.28053851, 0.28289252, 0.26908133, 0.26335034, 0.28409036, P < 0.05), residual volume/total lung capacity was negatively correlated to survival time (r = ?0.30760097, P < 0.05). Conclusions: The lung function decrease in the patients with lung cancer. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV), and residual volume/total lung capacity are correlated to survival time in patients with advanced lung cancer. The lung function indexes are important marker of prognosis of patients with lung cancer.

Keywords

Lung Function Indexes; Survival Time; Lung Cancer

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	A. Jemal, R. Siegel, E. Ward, et al., “Cancer Statistics, 2009,” CA: A Cancer Journal for Clinicians, Vol. 59, No. 4, 2009, pp. 225-249. doi:10.3322/caac.20006
[2]	J. Ferlay, H. R. Shin, F. Bray, et al., “Estimates of Worldwide Burden of Cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, Vol. 127, No. 12, 2010, pp. 2893-2917.doi:10.1002/ijc.25516
[3]	T. Iizasa, M. Suzuki, K. Yasufuku, et al., “Preoperative Pulmonary Function as a Prognostic Factor for Stage I Non-Small Cell Lung Carcinoma,” The Annals of Thoracic Surgery, Vol. 77, No. 6, 2004, pp. 1896-1902.
[4]	T. Win, A. Jackson, L. Sharples, et al., “Relationship between Pulmonary Function and Lung Cancer Surgical Outcome,” European Respiratory Journal, Vol. 25, No. 4, 2005, pp. 594-599. doi:10.1183/09031936.05.00077504
[5]	S. Raviv, K. A. Hawkins, M. M. DeCamp Jr., et al., “Lung Cancer in Chronic Obstructive Pulmonary Disease Enhancing Surgical Options and Outcomes,” American Journal of Respiratory and Critical Care Medicine, Vol. 183, No. 9, 2011, pp. 1138-1146. doi:10.1164/rccm.201008-1274CI
[6]	K. Yoshimatsu, N. K. Altorki, D. Golijanin, et al., “Inducible Prostaglandin E Synthase is Overexpressed in Non-Small Cell Lung Cancer,” Clinical Cancer Research, Vol. 7, No. 9, 2001, pp. 2669-2674.
[7]	S. Margaritora, A. Cesario, G. Gusumano, et al., “Is Pulmonary Function Damaged by Neoadjuvant Lung Cancer Therapy? A Comprehensive Serial Time-Trend Analysis of Pulmonary Function after Induction Radiochemotherapy Plus Surgery,” The Journal of Thoracic and Cardiovascular Surgery, Vol. 139, No. 6, 2010, pp. 1457-1463. doi:10.1016/j.jtcvs.2009.10.023
[8]	S. Takeda, Y. Funakoshi, Y. Kadota, et al., “Fall in Diffusing Capacity Associated with Induction Therapy for Lung Cancer: A Predictor of Postoperative Complication? The Annals of Thoracic Surgery, Vol. 82, No. 1, 2006, pp. 232-236. doi:10.1016/j.athoracsur.2006.01.045
[9]	S. Baser, V. R. Shannon, G. A. Eapen, et al., “Smoking Cessation after Diagnosis of Lung Cancer Is Associated with a Beneficial Effect on Performance Status,” Chest, Vol. 130, No. 6, 2006, pp. 1784-1790.
[10]	K. L. Tsai, E. Gupta and L. B. Haramati, “Pulmonary Atelectasis: A Frequent Alternative Diagnosis in Patients Undergoing CT-PA for Suspected Pulmonary Embolism,” Emergency Radiology, Vol. 10, No. 5, 2004, pp. 282-286. doi:10.1007/s10140-004-0328-5
[11]	A. G. Agustí, J. Cardús, J. Roca, et al., “Ventilation-Perfusion Mismatch in Patients with Pleural Effusion: Effects of Thoracentesis,” American Journal of Respiratory and Critical Care Medicine, Vol. 156, No. 4, 1997, pp. 1205-1209.
[12]	M. Reyhan, M. Aydin, A. Sukan, et al., “Ventilation-Perfusion Mismatch Secondary to Arterial Bullet Embolism,” Clinical Nuclear Medicine, Vol. 32, No. 4, 2007, pp. 330-332. doi:10.1097/01.rlu.0000256856.53656.b1
[13]	A. L. Cheville, A. M. Dose, J. R. Basford, et al., “Insights into the Reluctance of Patients with Late-Stage Cancer to Adopt Exercise as a Means to Reduce Their Symptoms and Improve Their Function,” Journal of Pain and Symptom Management, Vol. 44, No. 1, 2012, pp. 84-94. doi:10.1016/j.jpainsymman.2011.08.009