Share This Article:

Hospital Costs of Adverse Events in Patients with Metastatic Colorectal Cancer

Abstract Full-Text HTML XML Download Download as PDF (Size:141KB) PP. 153-158
DOI: 10.4236/jct.2013.41021    3,236 Downloads   5,134 Views   Citations

ABSTRACT

Background: Monoclonal antibody treatments for metastatic colorectal cancer (mCRC) have distinct treatment-related safety profiles. This study aimed to elucidate the hospitalisation costs of adverse events (AEs) commonly associated with monoclonal antibodies when administered to patients with mCRC. Methods: This study extracted data for patients newly diagnosed with mCRC from a large US claims database from January 2005 to June 2008. The first distant metastasis diagnosis date was defined as the index date. Main outcomes were length of hospital stay (days) and hospitalisation costs (2010 US$) for AEs (identified by primary discharge diagnoses). All analyses are presented descriptively. Results: The study population (aged ≥18 years; n = 12,648) was balanced according to gender and was mainly aged 50 years or older (90.1%). Most patients had colon cancer (70.1%) as opposed to rectal cancer. Gastrointestinal (GI) perforation incurred the longest median length of stay (11.5 days) for hospitalisations, followed by wound-healing complications (7 days), arterial and venous thromboembolism (5.5 and 4 days, respectively), and congestive heart failure (4 days). The highest inpatient cost per event was for GI perforations (mean $66,224 and median $ 34,027), followed by arterial thromboembolism ($40,992 and $18,587), wound-healing complications ($36,440 and $21,163), interstitial lung disease ($26,705 and $19,111) and acute myocardial infarction ($22,395 and $15,223). Skin toxicity (mean $6475 and median $6110) and hypertension ($14,108 and $6047) were associated with relatively low costs. Conclusions: Hospital costs for monoclonal antibody treatment-related AEs in patients with mCRC vary greatly. This study provides source data for economic evaluations of head-to-head comparisons of monoclonal antibody treatments.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

A. Fu, Z. Zhao, S. Wang, B. Barber and G. Liu, "Hospital Costs of Adverse Events in Patients with Metastatic Colorectal Cancer," Journal of Cancer Therapy, Vol. 4 No. 1, 2013, pp. 153-158. doi: 10.4236/jct.2013.41021.

References

[1] A. Jemal, R. Siegel, E. Ward, et al., “Cancer statistics, 2009,” CA: A Cancer Journal of Clinicians, Vol. 59, No. 4, 2009, pp. 225-249. doi:10.3322/caac.20006
[2] K. R. Yabroff, E. B. Lamont, A. Mariotto, et al., “Cost of Care for Elderly Cancer Patients in the United States,” Journal of the National Cancer Institute , Vol. 100, 2008, pp. 630-641. doi:10.1093/jnci/djn103
[3] X. Song, Z. Zhao, B. Barber, et al., “Characterizing medical care by disease phase in metastatic colorectal cancer,” Journal of Oncology Practice, Vol. 7, No. 3S, 2011, pp. 25s-30s. doi:10.1200/JOP.2011.000304
[4] J. Ortega, C. E. Vigil and C. Chodkiewicz, “Current Progress in Targeted Therapy for Colorectal Cancer,” Cancer Control, Vol. 17, No. 1, 2010, pp. 7-15.
[5] R. M. Goldberg, “Therapy for Metastatic Colorectal Cancer,” Oncologist, Vol. 11, No. 9, 2006, pp. 981-987. doi:10.1634/theoncologist.11-9-981
[6] Roche, “Bevacizumab US Prescribing Information,” 2010.
[7] Amgen Inc, “Panitumumab US Prescribing Information,” 2010.
[8] ImClone Systems Inc. and Bristol-Myers Squibb Company, “Cetuximab US prescribing information,” 2010.
[9] Roche, “Bevacizumab Summary of Product Characteristics,” 2010.
[10] Amgen Inc, “Panitumumab Summary of Product Characteristics,” 2010.
[11] ImClone Systems Inc. and Bristol-Myers Squibb Company, “Cetuximab Summary of Product Characteristics,” 2010.
[12] G. Dranitsaris, J. Maroun and A. Shah, “Estimating the Cost of Illness in Colorectal Cancer Patients Who Were Hospitalized for Severe Chemotherapy-Induced Diarrhea,” Canadian Journal of Gastroenterology, Vol. 19, No. 2, 2005, pp. 83-87.
[13] K. A. Foley, P. F. Wang, B. L. Barber, et al., “Clinical and Economic Impact of Infusion Reactions in Patients with Colorectal Cancer Treated with Cetuximab,” Annals of Oncology, Vol. 21, No. 7, 2010, pp. 1455-1461. doi:10.1093/annonc/mdp535
[14] “US Bureau of Labor Statistics,” 2010. http://www.bls.gov/cpi/

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.