Share This Article:

Ovarian cancer in Kenyatta National Hospital in Kenya: Characteristics and management

Abstract Full-Text HTML XML Download Download as PDF (Size:200KB) PP. 165-171
DOI: 10.4236/ojog.2013.31A031    4,270 Downloads   6,677 Views  

ABSTRACT

Background: Ovarian cancer is the third commonest cause of cancer death from gynaecologic tumors in Kenya. Early disease causes minimal, nonspecific, or no symptoms therefore, most patients are diagnosed when the disease is at an advanced stage. Overall, prognosis for these patients remains poor but has not been described in Kenya. Objectives: To describe the histological types, therapeutic methods used, therapeutic outcome and the survival rate at 2 years. Methods: This was a retrospective cross-sectional descriptive study undertaking a 10-year review of case records of patients treated for cancer of the ovary between 1998 and 2008 in Kenyatta National Hospital. Results: Majority of the patients (73.3%) presented with advanced stage of disease (stages III & IV). Epithelial tumors (86.2%) are the commonest histological type, with 45.7% of them being serous type. Chemotherapy was the most (46.0%) used therapeutic option, with vomiting and diarrhea being the leading morbidity associated with it. Survival at 2 yrs from diagnosis was 50% as per the Kaplan-Meier time survival estimate. Conclusion: There is need to improve the quality of data on cancer care and information systems in general to provide a reliable source of information to guide research and policy in oncology. Further, the late presentation to hospital calls for innovative strategies to improve ovarian cancer awareness and uptake of screening tests. There is need to lobby Governments in resource limited setting to subsidize cancer of the ovary care and invest in lower level health facilities to promote early diagnosis and decongest the referral hospital.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Cheserem, E. , Kihara, A. , Kosgei, R. , Gathara, D. and Gichuhi, S. (2013) Ovarian cancer in Kenyatta National Hospital in Kenya: Characteristics and management. Open Journal of Obstetrics and Gynecology, 3, 165-171. doi: 10.4236/ojog.2013.31A031.

References

[1] Lutz, A.M., Willmann, J.K., Drescher, C.W., Ray, P., Cochran, F.V., Urban, N., et al. (2009) Early diagnosis of ovarian carcinoma: Is a solution in sight? Radiology, 259, 329-45. doi:10.1148/radiol.11090563
[2] Hennessy, B.T., Coleman, R.L. and Markman, M. (2009) Ovarian cancer. The Lancet, 374, 1371-1382. doi:10.1016/S0140-6736(09)61338-6
[3] Odukogbe, A.A., Adebamowo, C.A., Ola, B., Olayemi, O., Oladokun, A., Adewole, I.F., et al. (2004) Ovarian cancer in Ibadan: Characteristics and management. Journal of Obstetrics and Gynaecology, 24, 294-297. doi:10.1080/01443610410001660904
[4] Sterling, L., van Lonkhuijzen, L., Nyangena, J., Orango, E., Strother, M., Busakhala, N., et al. (2011) Protocol development for ovarian cancer treatment in Kenya: A brief report. International Journal of Gynaecological Cancer, 21, 424-427.
[5] Reeler, A., Qiao, Y., Dare, L., Li, J., Zhang, A.L. and Saba, J. (2009) Women’s cancers in developing countries: From research to an integrated health systems approach. Asian Pacific Journal of Cancer Prevention, 10, 519-526.
[6] Gates, M.A., Rosner, B.A., Hecht, J.L. and Tworoger, S.S. (2010) Risk factors for epithelial ovarian cancer by histologic subtype. American Journal of Epidemiology, 171, 45-53. doi:10.1093/aje/kwp314
[7] Gharoro, E.P. and Eirewele, O. (2006) Cancer of the ovary at the University of Benin Teaching Hospital: A 10-year review, 1992-2001. African Journal of Medicine and Medical Sciences, 35, 143-147.
[8] Malik, I.A. (2002) A prospective study of clinico-pathological features of epithelial ovarian cancer in Pakistan. Journal of Pakistan Medical Association, 52, 155-158.
[9] Beral, V., Hermon, C., Peto, R., Reeves, G., Brinton, L., Marchbanks, P., Negri, E., Ness, R., Peeters, P.H.M., Vessey, M., et al. (2012) Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Medicine, 9, e1001200. doi:10.1371/journal.pmed.1001200
[10] Mwakyusa, S., Wamae, A., Wasunna, A., Were, F., Esamai, F., Ogutu, B., et al. (2006) Implementation of a structured paediatric admission record for district hospitals in Kenya—Results of a pilot study. BMC International Health Human Rights, 6, 9. doi:10.1186/1472-698X-6-9
[11] Irimu, G.W. Gathara, D., Zurovac, D., Kihara, H., Maina, C., Mwangi, J., Mbori-Ngacha, D., Todd, J., Greene, A. and English, M. (2012) Performance of health workers in the management of seriously sick children at a Kenyan Tertiary Hospital: Before and after a training intervention. PLoS ONE, 7, e39964. doi:10.1371/journal.pone.0039964

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.