Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve

Lin Xiong, Shouzhong Xiao, Qiang Zhou, Xianrong Wu, Zifu Xiao, Xingming Guo, Delin Lu, Wanrong Zhao, Xiaojun Wu, Xiaobo Yan, Yanxia Zhao, Jianming Liu

Chongqing Bo-Jing Medical Informatics Institute, Chongqing, China.
Chongqing Qingmuguan Central Hospital, Chongqing, China.
Department of Biomedical Engineering, Chongqing University, Chongqing, China.
Institute of Physical Education, Chongqing University, Chongqing, China.
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

DOI: 10.4236/jbise.2013.61001                

Abstract

Background: Since the greater part of coronary blood flow takes place during the diastolic phase of each cardiac cycle, a time indicator of myocardial perfusion reserve, the ratio of diastolic to systolic duration (D/S ratio), was presented. The objective of this study was to evaluate the accuracy and precision, the biological implication, and the applications of D/S ratio. Methods: Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve were performed. Related experiments, clinical trials, and surveys were conducted at 5 centers. Results: The results showed that the measurement of D/S ratio is both accurate and precise; the mean values of D/S of all of the 3 species studied (human, rabbit, and rat) were greater than 1. These application studies on D/S ratio showed that a close negative correlation existed between D/S ratio and New York Heart Association Functional Classification (NYHA FC) (r = –0.659, p < 0.01); normal persons were mostly distributed at NYHA FC I and at high value of D/S ratio; the patients with cardiovascular disease were mostly at low value of D/S ratio; the difference of D/S between pregnant women with pre-eclampsia and either normal pregnant women or non-pregnant women were significant (p < 0.05); athletes had higher D/S ratio than non-athletes (2.04 ± 0.33 vs 1.82 ± 0.27, p < 0.01). Conclusions: D/S ratio has important biological implication, which is a safe, easy, reliable, and effective indicator, can be used to evaluate fitness levels, served as a pathophysiological marker for screening of cardiovascular disease (CVD), for predicting risk of cardiac events, and for evaluating the severity and prognosis of CVD.

Keywords

Ratio of Diastolic to Systolic Duration (D/S); Accuracy; Precision; Cardiac Reserve; Cardiac Safety; Fitness

Conflicts of Interest

The authors declare no conflicts of interest.

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