Aqueous Two Phase Extraction for the Recovery of 1,3-Propanediol from Its Aqueous Solutions


As the biodiesel production is rapidly enhanced, the crude glycerol, which is by-product of biodiesel processes, is state of surplus. 1,3-PDO (1,3-propanediol), a valuable monomer of poly(trimethylene terephthalate) (PTT), can be produced from the fermentation process using crude glycerin as a carbon source. For the economic biological production of 1,3-PDO, the low cost and high efficient separation processes is essential. In this study, aqueous two-phase system composed of various hydrophilic alcohols and salt was used as a primary separation step for 1,3-PDO. It was found that the aqueous two-phase systems are easily formed with decreasing of the polarity of alcohols. The extraction efficiency is proportional to the polarity of alcohols. In case of methanol or ethanol/K2HPO4, the extraction efficiency was more than 90%.  It was concluded that the aqueous two-phase extraction using methanol or ethanol/K2HPO4 can be applied  for the primary separation of 1,3-PDO  as an alternative to a conventional primary separation processes.

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M. Chung, Y. Ki Hong, H. Wook Lee and S. Park, "Aqueous Two Phase Extraction for the Recovery of 1,3-Propanediol from Its Aqueous Solutions," Advances in Materials Physics and Chemistry, Vol. 2 No. 4B, 2012, pp. 154-157. doi: 10.4236/ampc.2012.24B040.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] M. A. Dasari, P. P. Kiatsimkul, W. R. Sutterlin and G. J. Suppes, “Low-pressure hydrogenolysis of glycerol to propylene glycol,” Applied Catalysis A: General, vol. 281, pp. 225-231, 2005.
[2] M. Pagliaro, R. Ciriminna, H. Kimura, M. Rossi and C D. Pina, “From glycerol to value-added products,” Angew. Chem. Int. Ed., vol. 46, pp. 4434-4440, 2007.
[3] R. K. Saxena, P. Anand, S. Saran and J. Isar, “Microbial production of 1,3-propanediol: Recent developments and emerging opportunities,” Biotech. Adv., vol. 27, pp. 895-913, 2009.
[4] Y. K. Hong, “Separation processes of biologically produced 1,3-propanediol,” Korean Chem. Eng. Res., in press.
[5] A. P. Zeng and H. Biebl, “Bulk chemicals from biotechnology: The case of 1,3-propanediol production and the new trends,” Adv. Biochem. Eng. Biotechnol., vol. 74, 00. 239-259, 2002.
[6] C. Raynaud, P. Sarcabal, I. Meynial-Sallas and C. Croux, “Molecular characterzation of the 1,3-propanediol operon of Clostridium butyricum,” Proc. Natl. Acad. Sci. USA, vol. 100, pp. 5010-5015, 2003.
[7] T. Homann, C. Tag, H. Biebl and W. Deckwer, “Fermentation of glycerol to 1,3-propanediol by Klebsiella and Citrobacter strains,” Appl. Microbiol. Biotechnol., vol. 33, pp. 121-126, 1990.
[8] Y. K. Hong, “Purification of 1,3-propanediol for production of polytrimethylene terephthalate(PTT) from biomass,” Adv. Mater. Res., vol. 320, pp. 191-195, 2011.
[9] Z.-L. Xiu and A.-P. Zeng, “Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol,” Appl. Microbiol. Biotechnol., vol. 78, pp. 917-926, 2008.
[10] R. R. Broekhuis, S. Lynn and C. J. King, “Recovery of propylene glycol from dilute aqueous solutions via reversible reaction with aldehydes,” Ind. Eng. Chem. Res., vol. 33, pp. 3230-3237, 1994.
[11] J. Hao, H. J. Liu and D. H. Liu, “Novel route of reactive extraction to recover 1,3-propanediol from a dilute aqueous solution,” Ind. Eng. Chem. Res., vol. 44, pp. 4380-4385, 2005.

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