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Pharmacological Adjuvants to Limit Erythropoietin Stimulating Agents Exposure

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DOI: 10.4236/ojneph.2012.24015    5,373 Downloads   8,520 Views   Citations

ABSTRACT

Anemia in chronic kidney disease (CKD) is common, causing morbidity and mortality, and is primarily due to reduced erythropoietin (EPO) release and, to a lesser degree, shortened red cell survival. Erythropoietin Stimulating Agents like epoetin Alfa and darbepoetin alpha are used commonly to treat this form of anemia. Recent evidence suggests increased morbidity and mortality associated with higher hemoglobin in the setting of these agents use. Whether these complications are due to higher dose of erythropoietin or its resistance (i.e. inflammation), or achieving a higher hemoglobin remains unclear. Tightening restrictions on these agents has led to increase interest in the use of non-ESA adjuvants to improve erythropoiesis. This review will highlight the most promising of these agents.

Cite this paper

I. Masood and G. Teehan, "Pharmacological Adjuvants to Limit Erythropoietin Stimulating Agents Exposure," Open Journal of Nephrology, Vol. 2 No. 4, 2012, pp. 86-96. doi: 10.4236/ojneph.2012.24015.

Conflicts of Interest

The authors declare no conflicts of interest.

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