Olanzapine-associated hypothermia in an adolescent anorexic girl

Martine K. F. Docx, Annik Simons, José Ramet, Luc Mertens, Paul Govaert

Department of Child Psychiatry, Queen Paola Children’s Hospital, Belgium and University of Antwerp, Antwerp, Belgium.
Department of Paediatrics, Queen Paola Children’s Hospital, Antwerp, Belgium.
Department of Paediatrics, University Hospital, Antwerp, Belgium.
Division of Cardiology, The Hospital for Sick Children, Toronto, Canada.

DOI: 10.4236/ojcd.2012.24017                

Abstract

This is a 12th case report on olanzapine induced hypothermia and based on the results of literature search, by far is the youngest case ever is reported. The hypothermia occurred during the refeeding phase, despite a weight gain since increasing the dosage from 5 mg to 7.5 mg olanzapine. Our recent literature search found 11 published cases of olanzapine treatment associated with hypothermia. Olanzapine acts on serotonin or dopamin receptors and has antagonistic properties on histaminergic, muscarinic and α-adrenergic receptors. Olanzapine mediates the hypothermic effect through antagonism at receptors other than dopamine.

Keywords

Anorexia Nervosa; Olanzapine; Hypothermia

Conflicts of Interest

The authors declare no conflicts of interest.

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