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Immunohistochemical Evaluation of Vascular Endothelial Growth Factor (VEGF) in Splenic Hemangiomas and Hemangiosarcomas in Dogs

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DOI: 10.4236/ojvm.2012.24030    4,893 Downloads   8,022 Views   Citations

ABSTRACT

Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

A. Gianotti Campos, J. Alvares Duarte Bonini Campos, D. Soares Sanches, M. Lúcia Zaidan Dagli and J. Maria Matera, "Immunohistochemical Evaluation of Vascular Endothelial Growth Factor (VEGF) in Splenic Hemangiomas and Hemangiosarcomas in Dogs," Open Journal of Veterinary Medicine, Vol. 2 No. 4, 2012, pp. 191-195. doi: 10.4236/ojvm.2012.24030.

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