Persistence of Pleural Effusions and Empyemas after Pneumococcal Conjugate Vaccine Implementation in Uruguay


In Uruguay a post pneumococcal conjugate vaccine implementation surveillance of hospitalized children with pneumonia showed an increase of complicated pneumonias, while uncomplicated pneumonias decreased. Out of 151 pleural effusions, 62 were empyemas requiring drainage, the rest of cases were treated with antibiotics with a favorable outcome. Patient’s vaccinated status varied. Pneumococcal etiology was poorly documented. The few identified sero-types were 1 and 3, a fact that urges PCV13 use for their control.

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M. Estevan, L. Martínez, E. Arreisengor and M. Hortal, "Persistence of Pleural Effusions and Empyemas after Pneumococcal Conjugate Vaccine Implementation in Uruguay," World Journal of Vaccines, Vol. 2 No. 4, 2012, pp. 179-181. doi: 10.4236/wjv.2012.24024.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S. T. Li and D. J. Tancredi, “Empyema Hospitalization Increased in US Children despite Pneumococcal Conjugate Vaccine,” Pediatrics, Vol. 125, No. 1, 2010, pp. 26-33. doi:10.1542/peds.2009-0184
[2] I. Obando, C. Mu?oz-Almagro, L. A. Arroyo, D. Tarrago, D. Sanchez, D. Moreno-Perez, et al., “Pediatric Parapneumonia Empyema, Spain,” Emerging Infectious Diseases Journal, Vol. 14, No. 9, 2006, pp. 1390-1397. doi:10.3201/eid1409.071094
[3] M. Hortal, G. Sehabiague, T. Camou, I. Iraola, M. Estevan and M. Pujadas, “Pneumococcal Pneumonia in Hospitalized Uruguayan Children and Potencial Prevention with Different Vaccine Formulations,” Journal of Pediatrics, Vol. 152, No. 6, 2008, pp. 850-853. doi:10.1016/j.jpeds.2007.11.008
[4] M. A. Fletcher, “More Severe Pneumococcal Pneumonia in Hospitalized Uruguayan Children,” Journal of Pediatrics, Vol. 154, No. 2, 2009, pp. 307-3028. doi:10.1016/j.jpeds.2008.09.020
[5] M. Hortal, M. Estevan, I. Iraola and B. De Mucio, “A Population-Based Assessment of the Disease Burden of Consolidated Pneumonia in Hospitalized Children under five Years of Age,” International Journal of Infectious Diseases, Vol. 11, No. 3, 2007, pp. 273-277. doi:10.1016/j.ijid.2006.05.006
[6] World Health Organization, Pneumonia Vaccine Trial Investigators Group, “Standardization of Interpretation of Chest Radiographs for the Diagnosis of Pneumonia in Children,” WHO, Geneva, 2001.
[7] C. L. Byington, K. Korgenski, J. Daly, K. Ampofo, A. Pavia and E. O. Mason, “Impact of the Pneumococcal Conjugate Vaccine on Pneumococcal Parapneumonia Empyema,” The Pediatric Infectious Disease Journal, Vol. 25, No. 3, 2006, pp. 250-254. doi:10.1097/01.inf.0000202137.37642.ab
[8] R. T. Chen and W. A. Orenstein, “Epidemiologic Methods Inimmunization Programs,” Epidemiologic Reviews, Vol. 18, No. 2, 1996, pp. 99-113. doi:10.1093/oxfordjournals.epirev.a017931
[9] Centers for Diseases Control and Prevention, “Pneumonia Hospitalizations among Young Children before and after Introduction of Pneumococcal Conjugate Vaccine. United States 1996-2006,” Morbidity and Mortality Weekly Report, Vol. 58, 2009, pp. 1-4.
[10] K. D. Schultz, L. L. Fan, J. Pinsky, L. Ochoa, E. O’Brian Smith, S. L. Kaplan, et al., “The Changing Face of Pleural Empyema in Children: Epidemiology and Management,” Pediatrics, Vol. 113, No. 6, 2004, pp. 1735-1740. doi:10.1542/peds.113.6.1735

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