Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report


Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.

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H. Binnenmars, H. Idzerda, H. Tan and G. Linssen, "Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report," International Journal of Clinical Medicine, Vol. 3 No. 6, 2012, pp. 513-517. doi: 10.4236/ijcm.2012.36092.

Conflicts of Interest

The authors declare no conflicts of interest.


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