Approaching intermolecular interactions and membrane activity of taxol by FTIR Spectroscopy-implications for anticancer therapeutics

Erhan Erhan Süleymanoglu

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DOI: 10.4236/health.2010.28125                

Abstract

We studied the incorporation of hydrophobic drug Taxol into a solid lipid matrices by FTIR spectroscopy. Lipid arrays containing different molar fractions of the drug were made and deposited on the spectrometer glass window substrates for obtaining multilayer stacks. The drug induced an alteration of lipid array spacings, indicating the drug-lipid recognition. Using excess amounts of Taxol provide information on extrapolations on its cellular solubility in biomembranes. The data obtained could be used further for developing novel anticancer drug formulations, as well as for elucidating its novel cellular pharmacological targets.

Keywords

Antineoplastic Drugs; Taxol-Membrane Interactions; Structural Changes; FTIR Spectroscopy

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Hennenfent, K.L. and Govindan, R. (2006) Novel formulations of taxanes: A review. Old wine in a new bottle? Annals of Oncology, 17(5), 735-749.
[2]	Kruh, G.D. (2005) Ins and outs of taxanes. Cancer Biology &Therapy, 4(9), 1030-1032.
[3]	Seydel, J.K. and Wiese, M. (2002) Drug-membrane interactions, analysis, drug distribution, modeling. In: Mannhold, R., Kubinyi, H. and Folkers, G., Eds., Methods and Principles in Medicinal Chemistry, Wiley-VCH Verlag GmbH, Weinheim, 15.
[4]	Günzler, H. and Gremlich, H.-U. (2002) IR spectroscopy. An introduction. Wiley-VCH Verlag GmbH, Weinheim, 69469.
[5]	Liggins, R.T., Hunter, W.L. and Burt, H.M. (1997) Solid- state characterization of paclitaxel. Journal of Pharmaceutical Sciences, 86(12), 1458-1463.
[6]	Lee, J.H., Gi, U.-S., Kim, J.-H., Kim, Y., Kim, S.-H., Oh, H. and Min, B. (2001) Preparation and characterization of solvent induced dihydrated, anhydrous, and amor- phous Paclitaxel. Bulletin of the Korean Chemical Society, 22(4), 925-928.
[7]	Farsad K. and De Camilli, P. (2003) Mechanisms of membrane deformation. Current Opinion in Cell Biology, 15(4), 372-381.