Comparison of High and Medium Iodine Concentrations of Contrast Materials for Preoperative CT Studies in Breast Cancer Patients


We compared the contrast effect of high and medium iodine-concentration contrast materials for preoperative CT eva- luation of breast cancer patients. Female breast cancer patients who underwent enhanced CT of the chest and upper abdomen before surgery were analyzed retrospectively. High (370 mg I/mL, 100 mL) or medium (300 mg I/mL, 125 mL) concentrations of contrast material were injected for 60 sec, followed by saline flush, and postcontrast CT images were obtained 90 sec after contrast injection. CT values were assessed for the breast tumor, normal breast parenchyma, liver, aorta, and muscle. For the high and medium concentration agents, 45 and 49 patients were analyzed, respectively. No significant differences between the two contrast agents were found in terms of CT values of the breast tumor, normal breast parenchyma, liver, aorta, or muscle. The tumor-background differences in CT values did not differ significantly between the two agents. A comparable contrast effect was indicated in single-phase CT of breast cancer patients between high and medium iodine-concentration contrast material when the total iodine dose and injection duration were identical.

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H. Yanaihara, Y. Inoue, K. Nagahara, H. Hata and R. Woodhams, "Comparison of High and Medium Iodine Concentrations of Contrast Materials for Preoperative CT Studies in Breast Cancer Patients," Open Journal of Medical Imaging, Vol. 2 No. 3, 2012, pp. 103-107. doi: 10.4236/ojmi.2012.23019.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Y. C. Cheung, S. C. Chen, S. H. Ueng, S. F. Ko and Y. L. Wan, “Dynamic Enhanced Computed Tomography Values of Locally Advanced Breast Cancers Predicting Axilla Nodal Metastasis after Neoadjuvant Chemotherapy,” Journal of Computer Assisted Tomography, Vol. 33, No. 3, 2009, pp. 422-425. doi:10.1097/RCT.0b013e31818521b3
[2] H. Kondo, M. Kanematsu, S. Goshima, Y. Tomita, M. J. Kim, N. Moriyama, et al., “Body Size Indexes for Optimizing Iodine Dose for Aortic and Hepatic Enhancement at Multidetector CT: Comparison of Total Body Weight, Lean Body Weight, and Blood Volume,” Radiology, Vol. 254, No. 1, 2010, pp. 163-169. doi:10.1148/radiol.09090369
[3] K. Awai, M. Inoue, Y. Yagyu, M. Watanabe, T. Sano, S. Nin, et al., “Moderate versus High Concentration of Contrast Material for Aortic and Hepatic Enhancement and Tumor-to-Liver Contrast at Multi-Detector Row CT,” Radiology, Vol. 233, No. 3, 2004, pp. 682-688. doi:10.1148/radiol.2333031617
[4] T. Ichikawa, S. M. Erturk and T. Araki, “Multiphasic Contrast-Enhanced Multidetector-Row CT of Liver: Contrast-Enhancement Theory and Practical Scan Protocol with a Combination of Fixed Injection Duration and Patients’ Body-Weight-Tailored Dose of Contrast Material,” European Journal of Radiology, Vol. 58, No. 2, 2006, pp. 165-176. doi:10.1016/j.ejrad.2005.11.037
[5] J. K. Han, A. Y. Kim, K. Y. Lee, J. B. Seo, T. K. Kim, B. I. Choi, et al., “Factors Influencing Vascular and Hepatic Enhancement at CT: Experimental Study on Injection Protocol Using a Canine Model,” Journal of Computer Assisted Tomography, Vol. 24, No. 3, 2000, pp. 400-406. doi:10.1097/00004728-200005000-00008
[6] L. R. Medeiros, C. S. Duarte, D. D. Rosa, M. I. Edelweiss, M. Edelweiss, F. R. Silva, et al., “Accuracy of Magnetic Resonance in Suspicious Breast Lesions: A Systematic Quantitative Review and Meta-Analysis,” Breast Cancer Research and Treatment, Vol. 126, No. 2, 2011, pp. 273285. doi:10.1007/s10549-010-1326-9
[7] C. K. Kuhl, “Current Status of Breast MR Imaging. Part 2. Clinical Applications,” Radiology, Vol. 244, No. 3, 2007, pp. 672-691. doi:10.1148/radiol.2443051661
[8] A. Perrone, L. L. Mele, S. Sassi, M. Marini, L. Testaverde, L. Izzo, et al., “MDCT of the Breast,” American Journal of Roentgenology, Vol. 190, No. 6, 2008, pp. 1644-1651. doi:10.2214/AJR.07.3145
[9] K. Miyake, K. Hayakawa, M. Nishino, Y. Nakamura, T. Morimoto, Y. Urata, et al., “Benign or Malignant? Differentiating Breast Lesions with Computed Tomography Attenuation Values on Dynamic Computed Tomography Mammography,” Journal of Computer Assisted Tomography, Vol. 29, No. 6, 2005, pp. 772-779. doi:10.1097/01.rct.0000178712.32547.53
[10] M. Inoue, T. Sano, R. Watai, R. Ashikaga, K. Ueda, M. Watatani, et al., “Dynamic Multidetector CT of Breast Tumors: Diagnostic Features and Comparison with Conventional Techniques,” American Journal of Roentgenology, Vol. 181, No. 3, 2003, pp. 679-686.
[11] M. Tozaki, T. Kobayashi, S. Uno, K. Aiba, H. Takeyama, H. Shioya, et al., “Breast-Conserving Surgery after Chemotherapy: Value of MDCT for Determining Tumor Distribution and Shrinkage Pattern,” American Journal of Roentgenology, Vol. 186, No. 2, 2006, pp. 431-439. doi:10.2214/AJR.04.1520
[12] H. Nakahara, K. Namba, H. Wakamatsu, R. Watanabe, H. Furusawa, M. Shirouzu, et al., “Extension of Breast Cancer: Comparison of CT and MRI,” Radiation Medicine, Vol. 20, No. 1, 2002, pp. 17-23.
[13] T. Uematsu, M. Sano, K. Homma, H. Makino, M. Shiina, S. Kobayashi, et al., “Staging of Palpable T1-2 Invasive Breast Cancer with Helical CT,” Breast Cancer, Vol. 8, No. 2, 2001, pp. 125-130. doi:10.1007/BF02967491
[14] S. Kuroki-Suzuki, Y. Kuroki, T. Ishikawa, H. Takeo and N. Moriyama, “Diagnosis of Breast Cancer with Multidetector Computed Tomography: Analysis of Optimal Delay Time after Contrast Media Injection,” Clinical Imaging, Vol. 34, No. 1, 2010, pp. 14-19. doi:10.1016/j.clinimag.2009.03.004
[15] P. Haage, T. Schmitz-Rode, D. Hübner, W. Piroth and R. W. Günther, “Reduction of Contrast Material Dose and Artifacts by a Saline Flush Using a Double Power Injector in Helical CT of the Thorax,” American Journal of Roentgenology, Vol. 174, No. 4, 2000, pp. 1049-1053.
[16] K. D. Hopper, T. J. Mosher, C. J. Kasales, T. R. TenHave, D. A. Tully and J. S. Weaver, “Thoracic Spiral CT: Delivery of Contrast Material Pushed with Injectable Saline Solution in a Power Injector,” Radiology, Vol. 205, No. 1, 1997, pp. 269-271.

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