Mycosis Fungoides: Epidemiology in Isfahan, Iran

DOI: 10.4236/jcdsa.2012.23043   PDF   HTML     3,234 Downloads   5,297 Views   Citations


Background: Mycosis Fungoides (MF) is the most common and indolent form of Cutaneuse T-cell Lymphomas (CTCL), that usually occurs in old adults. Objectives: To determine epidemiologic features and patients characteristics of MF in Isfahan (Iran). Methods: We performed a retrospective study in MF clinic of alzahra hospital that is the main center for treatment of MF patients in Isfahan (Iran) and evaluated clinicopathologic features. Results: In 3 years 25 patients were referred to Alzahra MF clinic. 18 patients diagnosed as MF. Seven (38.9%) patients were male and 11 (61.1%) were female with male to female ratio of 1:1.57. The mean age of patients was 41.06 years. 88.9% of our patients were in stages ΙA and ΙB. Conclusion: Most of our patients presented in early stages that were similar to other studies, while male: female ratio is different from other studies.

Share and Cite:

F. Naeini, J. Najafian, M. Salehi, Z. Azimi and P. Rajabi, "Mycosis Fungoides: Epidemiology in Isfahan, Iran," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 3, 2012, pp. 229-233. doi: 10.4236/jcdsa.2012.23043.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S. R. Parker and J. V. Bethaney, “Cutaneous T Cell Lymphoma-Mycosis Fungoides and Sezary Syndrome: An Update,” G Ital Dermatol Venereol, Vol. 144, No. 4, 2009, pp. 467-485.
[2] E. Samuelson, “Cutaneous T-Cell Lymphomas,” Seminars in Oncology Nursing, Vol. 14, No. 4, 1998, pp. 293-301. doi:10.1016/S0749-2081(98)80007-7
[3] M. A. Weinstock and B. Gardstein, “Twenty-Year Trends in the Reported Incidence of Mycosis Fungoides and Associated Mortality,” American Journal of Public Health, Vol. 89, No. 8, 1999, pp. 1240-1244. doi:10.2105/AJPH.89.8.1240
[4] S. P. Patel and O. A. Holtermann, “Mycosis Fungoides: An Overview,” Journal of Surgical Oncology, Vol. 22, No. 4, 1983, pp. 221-227. doi:10.1002/jso.2930220403
[5] S. M. Worobec-Victor, “Cutaneous T Cell Lymphoma,” New Jersey Medicine, Vol. 86, No. 5, 1989, pp. 395-400.
[6] N. Pimpinelli, E. A. Olsen, M. Santucci, E. Vonderheid, A. C. Haeffner, S. Stevens, et al., “Defining Early Mycosis Fungoides,” Journal of the American Academy of Dermatology, Vol. 53, No. 6, 2005, pp. 1053-1063. doi:10.1016/j.jaad.2005.08.057
[7] H. S. Zackheim and T. H. McCalmont, “Mycosis Fungoides: The Great Imitator,” Journal of the American Academy of Dermatology, Vol. 47, No. 6, 2002, pp. 914-918. doi:10.1067/mjd.2002.124696
[8] M. M. Morales-Suarez-Varela, J. Olsen, P. Johansen, L. Kaerlev, P. Guenel, P. Arveux, et al., “Occupational Risk Factors for Mycosis Fungoides: A European Multicenter Case-Control Study,” Journal of Occupational and Environmental Medicine, Vol. 46, No. 3, 2004, pp. 205-211. doi:10.1097/01.jom.0000116819.01813.8c
[9] A. S. Whittemore, E. A. Holly, I. M. Lee, E. A. Abel, R. M. Adams, B. J. Nickoloff, et al., “Mycosis Fungoides in Relation to Environmental Exposures and Immune Response: A Case-Control Study,” Journal of the National Cancer Institute, Vol. 81, No. 20, 1989, pp. 1560-1567. doi:10.1093/jnci/81.20.1560
[10] Y. Wohl and E. Tur, “Environmental Risk Factors for Mycosis Fungoides,” Current Problems in Dermatology, Vol. 35, 2007, pp. 52-64. doi:10.1159/000106410
[11] S. H. Swerdlow, E. Campo, N. L. Harris, E. S. Jaffe, A. S. Pileri, H. Stein, et al., “WHO Classification of Tumours of Haemopoietic and Lymphatic Tissue,” IARC Press, Lyon, 2008.
[12] E. Olsen, E. Vonderheid, N. Pimpinelli, R. Willemze, Y. Kim, R. Knobler, et al., “Revisions to the Staging and Classification of Mycosis Fungoides and Sezary Syndrome: A Proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC),” Blood, Vol. 110, No. 6, 2007, pp. 1713-1722. doi:10.1182/blood-2007-03-055749
[13] J. J. van Dongen, A. W. Langerak, M. Bruggemann, P. A. Evans, M. Hummel, F. L. Lavender, et al., “Design and Standardization of PCR Primers and Protocols for Detection of Clonal Immunoglobulin and T-Cell Receptor Gene Recombinations in Suspect Lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936,” Leukemia, Vol. 17, No. 12, 2003, pp. 2257-2317. doi:10.1038/sj.leu.2403202
[14] M. W. Lee, “Characteristics of Cutaneous Lymphomas in Korea,” Clinical and Experimental Dermatology, Vol. 28, No. 6, 2003, pp. 639-646. doi:10.1046/j.1365-2230.2003.01374.x
[15] C. Assaf, S. Gellrich, M. Steinhoff, D. Nashan, F. Weisse, E. Dippel, et al., “Cutaneous Lymphomas in Germany: An Analysis of the Central Cutaneous Lymphoma Registry of the German Society of Dermatology (DDG),” Journal der Deutschen Dermatologischen Gesellschaft, Vol. 5, No. 8, 2007, pp. 662-668. doi:10.1111/j.1610-0387.2007.06337.x
[16] T. Ishiji, Y. Takagi and M. Niimura, “Cutaneous Lymphomas in Tokyo: Analysis of 62 Cases in A Dermatology Clinic,” International Journal of Dermatology, Vol. 40, No. 1, 2001, pp. 37-40.
[17] N. McFadden, A. Nyfors, G. Tanum, A. Granholt, P. Helme and G. Kavli, “Mycosis Fungoides in Norway 1960-1980. A Retrospective Study,” Acta Derm Venereol Suppl (Stockh), Vol. 109, 1983, pp. 1-13.
[18] V. D. Criscione and M. A. Weinstock, “Incidence of Cutaneous T-Cell Lymphoma in the United States, 1973-2002,” Archives of Dermatology, Vol. 143, No. 7, 2007, pp. 854-859. doi:10.1001/archderm.143.7.854
[19] K. A. Gurney and R. A. Cartwright, “Increasing Incidence and Descriptive Epidemiology of Extranodal Non-Hodgkin lymphoma in Parts of England and Wales,” The Hematology Journal, Vol. 3, No. 2, 2002, pp. 95-104. doi:10.1038/sj.thj.6200154
[20] L. S. Ku and K. K. Lo, “Mycosis Fungoides—A Retrospective Study of 40 Cases in Hong Kong,” International Journal of Dermatology, Vol. 44, No. 3, 2005, pp. 215-220. doi:10.1111/j.1365-4632.2004.02362.x
[21] H. Hamideh, A. Hamideh, G. Farideh and Y. Neda, “Demographic and Clinical Features of Mycosis Fungoides in Tabriz, Iran,” Iranian Journal of Medical Sciences, Vol. 34, No. 2, 2009, p. 152.
[22] A. R. Khooei and M. R. Keramat, “Cutaneous Lymphomas and Pseudolymphomas: A Ten-Year Study at Emam Reza and Omid Hospitals in Mashhad, Using Immunohistochemical and New Classification Methods,” Iranian Journal of Dermatology, Vol. 31, No. 8, 2005, pp. 201-210.
[23] H. M. Manuchehri and M. Rakhshan, “Characteristics of Primary Cutaneous Lymphomas in Tehran, Iran (1998-2004),” Journal of the European Academy of Dermatology and Venereology, Vol. 20, No. 6, 2006, pp. 758-760. doi:10.1111/j.1468-3083.2006.01536.x
[24] M. Salehi, Z. Azimi, F. Fatemi, P. Rajabi, M. Kazemi and G. Amini, “Incidence Rate of Mycosis Fungoides in Isfahan (Iran),” The Journal of Dermatology, Vol. 37, No. 8, 2010, pp. 703-707. doi:10.1111/j.1346-8138.2010.00899.x
[25] E. J. Kim, J. Lin, J. M. Junkins-Hopkins, C. C. Vittorio and A. H. Rook, “Mycosis Fungoides and Sezary Syndrome: An Update,” Current Oncology Reports, Vol. 8, No. 5, 2006, pp. 376-386. doi:10.1007/s11912-006-0061-1
[26] P. L. Zinzani, A. J. Ferreri and L. Cerroni, “Mycosis Fungoides,” Critical Reviews in Oncology/Hematology, Vol. 65, No. 2, 2008, pp. 172-182. doi:10.1016/j.critrevonc.2007.08.004
[27] E. S. Tan, M. B. Tang and S. H. Tan, “Retrospective 5-Year Review of 131 Patients with Mycosis Fungoides and Sezary Syndrome Seen at the National Skin Centre, Singapore,” Australasian Journal of Dermatology, Vol. 47, No. 4, 2006, pp. 248-252. doi:10.1111/j.1440-0960.2006.00290.x
[28] Q. A. Alsaleh, A. Nanda, H. Al-Ajmi, H. Al-Sabah, M. Elkashlan, S. Al-Shemmari, et al., “Clinicoepidemiological Features of Mycosis Fungoides in Kuwait, 1991-2006,” International Journal of Dermatology, Vol. 49, No. 12, 2010, pp. 1393-1398.
[29] R. van Doom, C. W. Van Haselen, et al., “Mycosis Fungoides: Disease Evolution and Prognosis of 309 Dutch Patients,” Archives of Dermatology, Vol. 136, No. 4, 2000, pp. 504-510. doi:10.1001/archderm.136.4.504
[30] S. E. Thurber, B. Zhang, Y. H. Kim, I. Schrijver, J. Zehnder and S. Kohler, “T-Cell Clonality Analysis in Biopsy Specimens from Two Different Skin Sites Shows High Specificity in the Diagnosis of Patients with Suggested Mycosis Fungoides,” Journal of the American Academy of Dermatology, Vol. 57, No. 5, 2007, pp. 782-790. doi:10.1016/j.jaad.2007.06.004
[31] C. Xu, C. Wan, L. Wang, H. J. Yang, Y. Tang and W. P. Liu, “Diagnostic Significance of TCR Gene Clonal Rearrangement Analysis in Early Mycosis Fungoides,” Chinese Journal of Cancer, Vol. 30, No. 4, 2011, pp. 264-272. doi:10.5732/cjc.010.10344
[32] P. F. Hsiao, C. H. Hsiao, Y. C. Lin, M. P. Tseng, T. F. Tsai and S. H. Jee, “Histopathologic-Molecular Correlation in Early Mycosis Fungoides Using T-Cell Receptor Gamma Gene Rearrangement by Polymerase Chain Reaction with Laser Capture Microdissection,” Journal of the Formosan Medical Association, Vol. 106, No. 4, 2007, pp. 265-272. doi:10.1016/S0929-6646(09)60251-5
[33] S. L. Kandolf, B. Cikota, O. Stojadinovic, J. Basanovic, D. Skiljevic, L. Medenica, et al., “TCRgamma Gene Rearrangement Analysis in Skin Samples and Peripheral Blood of Mycosis Fungoides Patients,” Acta Dermatovenerol Alp Panonica Adriat, Vol. 16, No. 4, 2007, pp. 149-155.
[34] M. M. Morales-Suarez-Varela, J. Olsen, P. Johansen, L. Kaerlev, P. Guenel, P. Arveux, et al., “Occupational Exposures and Mycosis Fungoides. A European Multicentre Case-Control Study (Europe),” Cancer Causes Control, Vol. 16, No. 10, 2005, pp. 1253-1259. doi:10.1007/s10552-005-0456-6
[35] M. M. Morales-Suarez-Varela, J. Olsen, P. Johansen, L. Kaerlev, P. Guenel, P. Arveux, et al., “Occupational Sun Exposure and Mycosis Fungoides: A European Multicenter Case-Control Study,” Journal of Occupational and Environmental Medicine, Vol. 48, No. 4, 2006, pp. 390-393. doi:10.1097/01.jom.0000194160.95468.20

comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.