Efficacy of static magnetic field for pain of adjuvant arthritis rats


Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Following SMF stimulation, we measured blood flow volume in the paw and then reactive speed response to thermal stimulation. The AA groups exhibited significantly lower blood volume and reactivity to thermal stimulation compared to the control group. Compared to non-SMF, SMF exhibited increased blood flow volume in both the tail and paw, along with an increased reactive speed response to thermal stimulation. Our findings suggest that an improved of blood flow and reactive speed response, induced by SMF, appears to be effective for the relief of pain induced by chronic inflammation.

Share and Cite:

Kanai, S. and Taniguchi, N. (2012) Efficacy of static magnetic field for pain of adjuvant arthritis rats. Advances in Bioscience and Biotechnology, 3, 511-515. doi: 10.4236/abb.2012.324067.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Veliks V, Ceihnere E, Svkis I and Aivars J (2004) Static magnetic field influence on rat brain function detected by heart rate monitoring. Bioelectromagnetics 25, 211-215.
[2] Morris CE, Skalak TC. (2008) Magnetic therapy for edema in inflammation: a physiological assessment. American Journal of Physiology-Heart and Circulatory Physiology. 294, H50-57.
[3] Gmitrov J, Ohkubo C, Okano H (2002) Effect of 0.25 T static magnetic field on microcirculation in rabbits. Bioelectromagnetics. 23, 224-229.
[4] Xu S, Okano H, Ohkubo C (2001) Acute effects of whole-body exposure to static magnetic fields and 50-Hz electromagnetic fields on muscle microcirculation in anesthetized mice. Bioelectrochemistry. 53, 127-35.
[5] Okano H, Ohkubo C (2005) Effects of neck exposure to 5.5 mT static magnetic field on pharmacologically modulated blood pressure in conscious rabbits. Bioelectro-magnetics. 26, 469-480.
[6] Okano H, Ohkubo C (2005) Exposure to a moderate intensity static magnetic field enhances the hypotensive effect of a calcium channel blocker in spontaneously hypertensive rats. Bioelectromagnetics. 26, 611-623.
[7] Okano H, Ohkubo C (2007) Effects of 12 mT static magnetic field on sympathetic agonist-induced hypertension in Wistar rats. Bioelectromagnetics 28, 369-378.
[8] Kotani H, Kawaguchi H, Shimoaka T, Iwasaka M, Ueno S, Ozawa H, Nakamura K and Hoshi K (2002) Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Journal of Bone and Mineral Research 17, 1814-1821.
[9] Singh P, YashRoy R and Hoque M (2006) Augmented bone-matrix formation and osteogenesis under magnetic field stimulation in vivo TEM and SEM investigations. Indian Journal of Biochemistry and Biophysics 43, 167-172.
[10] Xu S, Okano H, Tomita N, Ikada Y(2011) Recovery Effects of a 180 mT Static Magnetic Field on Bone Mineral Density of Osteoporotic Lumbar Vertebrae in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine 2011, online 620984.
[11] Segal A, N, Toda Y, Huston J and Saeki Y (2001) Two configurations of static magnetic fields for treating rheumatoid arthritis of the knee: A double-blind clinical trial. Archives of Physical Medicine and Rehabilitation 82, 1453-1460.
[12] Harlow T, Greaves C, White A, Brown L, Hart A, Ernst E. (2004) Randomised controlled trial of magnetic bracelets for relieving pain in osteoarthritis of the hip and knee. British Medical Journal 18, 1450-1454.
[13] Chen CY, Chen CL, Hsu SC, Chou SW, Wang KC (2008) Effect of magnetic knee wrap on quadriceps strength in patients with symptomatic knee osteoarthritis. Archives of Physical Medicine and Rehabilitation 89, 2258-2264.
[14] Kanai S, Taniguchi N, Kawamoto, M, Endo,H and Higashino H. (2004) Effect of static magnetic field on pain associated with frozen shoulder. THE PAIN CLINIC 16, 173-179.
[15] Kanai S, Taniguchi N. (2006) Effect of polarity exchangeable permanent magnet on frozen shoulder pain. THE PAIN CLINIC 18, 37-45.
[16] Kanai S, Taniguchi N and Okano H (2011) Effect of Magnetotherapeutic Device on Pain Associated With Neck and Shoulder Stiffness. Alternative Therapies in Health and Medicine 17, 44-48.
[17] Matsuhata I, Taniguchi N, Kanai S (2006) Study of Electro-Acupuncture Therapy (muscle-EAT) for adjuvant-induced arthritis in rats. Kanpo Medcine 57, 437 - 442.
[18] Kim HR, Rajaiah R, Wu QL, Satpute SR, Tan MT, Simon JE, Berman BM (2008) Green tea protects rats against autoimmune arthritis by modulating disease-related immune events. The Journal of Nutrition 138, 2111-2116.
[19] Tamaki K, Taniguchi N, Matsuhata I, Kanai S (2005) Effects of moxibustion and gosya-zinnki-gann for spontaneous fatty diabetes rat. Kanpo Medcine 56, 555-560.
[20] Pekrkova I, Parara S, Holecek V, Stopka P, Trefil L, Racek J, Rokyta R (2001) Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? Physiological Research 50 595-602.
[21] Kanai S, Take A and Taniguchi N. (2000) Study of moxibusition for experimental arthritis model rat. Oriental Medicine and the Pain Clinic 30, 16-21.
[22] Taniguchi N, Kanai S, Kawamoto M, Endo H, and Higashino H (2004) Study on application of static magnetic field for adjuvant arthritis rats. Evidence-Based Complementary and Alternative Medicine 1, 187-192.
[23] Omoto A, Kawahito Y, Prudovsky I, Tubouchi Y, Kimura M, Ishino H, Wada M, Yoshida M, Kohno M, Yoshimura R, Yoshikawa T, Sano H (2005) Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats. Arthritis Research & Therapy 7, R 1174-1182.
[24] Perera PK, Li Y, Peng C, Fang W, Han C (2010) Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis. Indian Journal of Pharmacology 42 65-69.
[25] Takeshige C, Sato M (1996) Comparisons of pain relief mechanisms between needling to the muscle, static magnetic field, external qigong and needing to the acupuncture point. Acupuncture & electro-therapeutics research 21, 119-131.

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.