Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus


Effects a synthetic Aluminium-Magnesium Silicate [AMS] has on Avian Influenza Virus (AIV) were tested. Equal amounts of AIV samples and of the AMS were mixed, kept one hour at room temperature before centrifuging. The supernatants were remeasured and tested for, viral titre, Mean Death Time (MDT) and Mortality Rate of chicken Embryos (EMR). Volumes of the viral samples reduced at rate of 23.4% ± 5.48%. Viral titres reduced significantly (P < 0.01) from HA, 73 ± 32.72 to 1.4 ± 0.43. Also, EMR of infected chicken embryos reduced from 100% to 65%, while MDT of those that died,increased significantly (P < 0.01) from 76 ± 4.38 to 136 ±18.93 hours. When incubation with AMS was repeated on portions of an AIV sample, MDT increased from 64 to 104 hours with the portion incubated once. AIV portions on which incubation with AMS was repeated could not kill chicken embryos.

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Ezeibe, M. , Egbuji, A. , Okoroafor, O. , Eze, J. , Ijabo, O. , Ngene, A. , Eze, I. , Ugonabo, J. , Sanda, M. and Mbuko, I. (2012) Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus. Health, 4, 429-432. doi: 10.4236/health.2012.47067.

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The authors declare no conflicts of interest.


[1] Jordan, F.W.T. (1990) Poultry diseases. 3rd Edititon, Bailliere Tindal, London.
[2] Webster, R.G., Peiris, M., Chen, H. and Guan, Y. (2006) H5N1 outbreaks and enzootic influenza. Emerging Infectious Diseases, 12, 3-8. doi:10.3201/eid1201.051024
[3] WHO (2005) Avian influenza Virus A (H5N1) infection in humans: Urgent need to eliminate the animal reservoirs. http/
[4] Monne, I., et al. (2008) Resortant Avian Influenza Virus (H5N1) in poultry in Nigeria in 2007. Emerging Infectious Diseases, 14, 637-640. doi:10.3201/eid1404.071178
[5] Verndabilt, R.T. (1992) Inc. Technical Literature: Veegum? the versatile incredient for pharmaceutical formulations. 1-5.
[6] Venkatakrishnan, R. (1995) Geology—An introduction to physical geology. Worth Publishers, New York.
[7] Cann, A.J. (1993) Principles of molecular virology. Academic Press, Cambridge.
[8] Ezeibe, M.C.O. (2006) Admacine?. Federal Republic of Nigeria Patents No. 16448
[9] Johnson, R.H. (1971) Serological procedures for the study of Feline panleukopaenia. Journal of the American Veterinary Medical Association, 158, 876-884.
[10] Brooks, G.F. (1998) Medical microbiology. 21st Edition, Mc Graw Hill education Inc., SanFranscisco.
[11] Stern, I.B., Greenberg, M., Gersoni, J.M. and Rozenblatt, S. (1995) The haemaglutinin envelope protein of Canine distemper virus (CDV) confers cell tropism as illustrated by CDV—Measles virus complementation analysis. Journal of Virology, 69, 1661-1668.
[12] Ezeibe, M.C.O., et al. (2009) Antiviral effects of Aluminium- Magnesium Silicate on Peste des Petits Ruminants Virus. Animal Science Papers and Reports, 3, 141-147.
[13] Ezeibe, M.C.O., et al. (2009) In vitro and in vivo effects of Aluminium-Magnesium Silicate on Infectious Bursal Disease Virus of chickens. Animal Science Papers and Reports, 3, 132-137.
[14] Ezeibe, M.C.O., et al. (2010) Haemagglutination and Hae- magglutination-Inhibition titres of Egg Drop Syndrome 76 Virus treated with Aluminium-Magnesium Silicate. Animal Science Papers and Reports, 4, 87-90.
[15] Ezeibe, M.C.O., et al. (2010) Aluminium-Magnesium Silicate inhibits Canine Parvovirus and cures infected dogs. Health, 2, 1215-1217. doi:10.4236/health.2010.210179
[16] Ezeibe, M.C.O., et al. (2011) Effects of Aluminium-Magnesium Silicate on Newcastle Disease Virus and on recovery of infected chicks. International Journal of Biological Chemistry, 5, 835-839.
[17] Windholz, M.B. (1978) The Merck index. Merck and Co. Inc., New Jersey.
[18] Foster, E. and Smith, K. (2007) Aluminium-Magnesium Silicate used as antacid, antiulcer and to control diarrhea. Journal of Renal Nutrition, 4, 5053.
[19] Greene, C.E. (1990) Infectious diseases of dogs and cats. W. B. Saunders, Philadephia.
[20] Murray, K.R. (2000) Harpers biochemistry. McGraw Hill, New York.

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