Share This Article:

The Properties of Nanohydroxyapatite Materials and its Biological Effects

Abstract Full-Text HTML Download Download as PDF (Size:1006KB) PP. 81-90
DOI: 10.4236/msa.2010.12015    5,925 Downloads   10,605 Views   Citations

ABSTRACT

The nanohydroxyapatites (HAP) and its biological effects have been studied using ultraviolet absorption spectrum, X-ray diffraction (XRD) structure analysis, fluorescent and infrared spectrum of absorption and MTT method. The nanohyd- roxyapatites are prepared and made by using Sol-gel method, in which the parameters of process and reaction are controlled as: PH > 9, Ca/P = 1.67, sintering temperature of 1100?C and sintering time 2 hours. The results of the study show that nanohydroxyapatites can absorb the amino acid molecules, the absorption is better for stronger acidity of amino acids. We also find that the nanohydroxyapatites and complex of nanoHAP+ nanoCrO2 can all restrain the proliferation of cells, but their toxiciteis are all first degree or minor, but the restrained effect of the latter is smaller than that of the former, although they can decrease the relative proliferation rate of cells. The nanohydroxyapatites can also change the molecular structure of human serum albumin.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

X. Pang, H. Zeng, J. Liu, S. Wei and Y. Zheng, "The Properties of Nanohydroxyapatite Materials and its Biological Effects," Materials Sciences and Applications, Vol. 1 No. 2, 2010, pp. 81-90. doi: 10.4236/msa.2010.12015.

References

[1] R. R. Liu, X. Mao, Q. C. Yu, et al., “Preparation of Bioactive Nanohydroxya-Patite Coating for Artificial Cornea,” Current Applied Physics, Vol. 7, No. 1, 2007, pp. 85-89.
[2] Z. J. Wu, L. P. He and Z. Z. Chen, “Fabrication and Characterization of Hydroxyapa-Tite/Al2O3 Biocomposite Coating to Titanium,” The Transactions of Nonferrous Metals Society of China, Vol. 16, No. 3, 2006, pp. 259- 266.
[3] C. S. Chai and B. Bennissan, “Bioactive Nanocrystalline Sol-Gel Hydroxyapatite Coatings,” Journal of Materials Science: Materials in Medicine, Vol. 10, No. 4, 1999, pp. 465-469.
[4] F. L. Yu, Y. Q. Zhou, W. K. Zhang and J. Y. Ma, “Prep-aration and Development Prospects of Research of Hydroxyapatite Biomaterials,” Ceramics, Vol. 23, No. 2, 2006, pp. 6-11.
[5] A. Bennick, M. Cannon and G. Madapallimattam, “He Nature of the Hydroxyapatite-Binding Site in Salivary Acidic Proline-Rich Proteins,” Biochemical Journal, Vol. 183, No. 1, 1979, pp. 115-126.
[6] Q. Ye, R. Hu, Z. Y. Lin and C. J. Lin, “Hydroxyl Apatite and Bovine Serum Albumin Interactions in Situ Infrared Spectroscopy,” Chemical Journal, Vol. 26, No. 8, 2006, pp. 946-950.
[7] Z. Q. Situ and J. Z. Wu, “Cluture of Cell,” World Book Publishing Company, Beijing, 1996, pp. 186-187.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.