Nucleation Reduction Strategy of (Brushite) CHP Crystals in SMS Media and Its Characterization Studies

DOI: 10.4236/jmmce.2008.71004   PDF   HTML     4,388 Downloads   5,299 Views   Citations


Kidney stone consist of various organic, inorganic and semi organic compounds. Mineral oxalate monohydrate and di-hydrate is the main inorganic constituent of kidney stones. However, the mechanisms for the formation of calcium oxalate kidney stone are not clearly understood. In this field of study there are several hypothesis including nucleation, crystal growth and or aggregation of formation of COMH, AOMH (Ammonium oxalate monohydrate), CODH, and AODH (Ammonium oxalate di-hydrate) crystals. The author has reported the effect of some urinary species such as ammonium oxalates, calcium, citrate, proteins and trace mineral. The kidney stone constituents are grown in the kidney environments, the silica gel medium (SMS) provides the necessary growth simulation (in-vivo). In the artificial urinary stone preparation (growth) or crystal growth, growth parameter identification with in the different chemical environments is carried out. In the present study, CHP (calcium hydrogen phosphate) crystals are grown in three different growth faces to attain the total nucleation reductions. As an extension of this research, many characterization studies have been carried out, and the results are compared and reported.

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G. Kanchana, P. Sundaramoorthi, R. Santhi, S. Kalainathan and G. Jeyanthi, "Nucleation Reduction Strategy of (Brushite) CHP Crystals in SMS Media and Its Characterization Studies," Journal of Minerals and Materials Characterization and Engineering, Vol. 7 No. 1, 2008, pp. 49-57. doi: 10.4236/jmmce.2008.71004.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S.R.Khan,P.O.Whalen, and P.A.Glenton,J.Cryst.Growth 134,211(1993).
[2] W.H.Boyce,Am.J.Med. 45 (5), 673 (1968).
[3] H.G.Tiselius,Clin.Chim.Acta.122, 409 (1982).
[4] R.W.Marshall and W.G.Robertson,Clin.Chim.Acta.72, 253 (1976).
[5] S.R.Khan,Urol.Int 59, 59 (1997).
[6] R.L.Ryall,A.M.F.Stapleton,in calcium oxalate in Biological system,Eds.S.R.Khan (CRC press) (1995).
[7] C.G.Duarte and F.G.Knox, in text book of renal pathophysiology, (Harper and Row ,(1978).
[8] F.L.Coe,J.H.Parks, and J.R.Asplin,N.Engl.J.Med.327,1141(1992)
[9] Maurice Audran and Erick Legrand,Joint Bone spine 67 (6),509 (2000).
[10] Y.Ogawa,T.miyazato, and T.Hataano,World j.Surgery 24 (10),1154 (2000).
[11] D.S.Goldfarb and F.L.Coe, Am.Fam.Physicican.60 (8) 2269 (2000).
[12] D.P.Simpson,Am.J.Physiol.224(3), F223 (1983).
[13] J.L.Mayer andL.Hsmith,Invest.Urol 13, 36 (1975).
[14] M.J.Nicar,K.Hill and C.Y.C.pack,J.Bone ,Miner.Res.2 (3), 215 (1987)
[15] D.J.Kok,S.E.Papapoulus,and O.L.M.Bijvoet,Lancet41,1056 (1986).
[16] C.Y.C. Pakand Paterson, Arch.Intern.Med.146, 863 (1986).
[17] B.Hess,Miner.Electr.Metab 20,393 (1996)
[18] C.Y.C.Pak,Hypocitraturia; a critical review and furture direction,from 8 th European symposium on Urolithiasis-Parma,Italy,June 9-12 (1999).
[19] A.Mersmann,Crystallization technology,Hand book,2nd Edi. Marcel Dekker,Inc.(2000).
[20] V.A.Garten and R.B.Head,Phil.Mag.14, 1243 (1966).
[21] D.J.Kok,The role of crystallization process in mineral oxlates urolithasis, Ph.D thesis,Univerasity of Leiden (1991).
[22] Henisch, H.K. etal,J Electro Chemical. Soc.,112 (1965) 627.
[23] A.E.Alexander, and P.Honson, Colloid Science ,Clarendon Press, Oxford,(1949).
[24] W.Eitel, In:Physical chemistry of Silicate University of Chicago Press,(1954).
[25] Yean. Chin etal ’Application of IR Spectroscopy to analysis of uninary calculi J. Urol. Vol 86, (1961) 838-854.
[26] C.M. Corns ”Infrared analysis of real Calculi – a comparison with conventional Techniques”Ann. Clin. Bio-Cherm, Vol 20, (1983) 20-35.
[27] A.Hesse , D. Bach,. Stone analysis by IR spectroscopy, Clinical and laboratory Aspects, Edi.Alan Rose, University Park Press, Baltimore, (1982), 87-105.
[28] J.J.Gilman, J.,Johnsion and G.W.Sears , J.Appl.Physics., 29,(1958) 749.
[29] J.J. Gilman., etal, , J.Appl.Physics, 27,(1956)1018.
[30] J.C.Fisher, in: Dissolutions and Mechanical Properties of Crystals, John Wiley and sons, NewYork (1957).
[31] J.B. New Kirk., In:Director observation of Imperfection in crystals, Interscience Publisers, New York (1962).
[32] K. Taukamot, J. Cryst. Growth, 61, (1983) 99.
[33] H.C.Gates, Thirty years of progress in Surface Science, in: Crystal growth and characterization,(Edi),North Holland (1975).
[34] H.Bethage etal, Electron Microscopy in Solid State Physics, Elsever, Amsterdom (1987)
[35] N. Albon etal, in: Growth and Perfection of Crystals, Wiley, New York, P.44 (1958).
[36] P.Sundaramoorthi, S.Kalainathan, Asian journal of chemistry,19-4, (2007).
[37] B.D.Hess and D.J.kok, Nucleation, Growth and aggregation of stone- Forming crystals, In Kidney stones: Medical and surgical management eds.F.L.Coe et al (Lippincott-Raen.publishers), (1996).
[38] L.Addadi,A.Berman,J.Moradian-Oldk,and S.Weiner,Connect Tiss.Res.21,127-135 (1989).
[39] S.Deganello, Calcif.Tiss.Int.48, 421 (1991).
[40] S.R.khan, Urol.Int.59, 59 (1997).

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