Microangiopathic Hemolytic Anemia and Diffuse Bone Metastasis by Signet Ring Cell Adenocarcinoma


Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome and is typically associated with gastric adenocarcinoma. We report a 47-year-old woman who presented with asthenia, lower back pain and bleeding. Twelve years ago the patient underwent total gastrectomy due to gastric adenocarcinoma and achieved complete remission. The patient was diagnosed with MAHA and diffuses bone metastasis of signet ring cell adenocarcinoma of unknown origin and was treated successfully with polichemotherapy based on cisplatin and 5-fluorouracil.x

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A. Martín, P. Alfonso, M. Martínez, V. Marín, Y. Gilarranz, R. Solís and M. Jiménez, "Microangiopathic Hemolytic Anemia and Diffuse Bone Metastasis by Signet Ring Cell Adenocarcinoma," Journal of Cancer Therapy, Vol. 1 No. 2, 2010, pp. 94-96. doi: 10.4236/jct.2010.12016.

Conflicts of Interest

The authors declare no conflicts of interest.


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