Hypopigmented Mycosis Fungoides in a 7-Year-Old Boy

Abstract

Hypopigmented mycosis fungoides (HMF) is an uncommon variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned people, particularly children. The HMF diagnose is difficult, especially in early stages because this condition resembles benign skin diseases. Thus is histopathological analysis very important for the diagnosis. We report a case of a 7-year-old child with widespread HMF confirmed by histopathology that showed cells tagging along the dermal/epidermal junction and extending into the epidermis in a pattern of epidermotropism and focal cell aggregates in the epidermis (Pautrier’s microabscess). We demonstrate the importance of clinical suspicion for this cutaneous neoplasia in patients with hypopigmentated lesions.

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F. Nazareth, M. Victoria Quaresma, F. Bernardes, C. Gustavo Carneiro Castro, E. Pellegrini Nahn, J. Augusto da Costa Nery, M. Carrijo Rochael and O. Lupi, "Hypopigmented Mycosis Fungoides in a 7-Year-Old Boy," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 2, 2012, pp. 64-67. doi: 10.4236/jcdsa.2012.22015.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] N. Onsun, Y. Kural, O. Su, et al., “Hypopigmented Mycosis Fungoides Associated with Atopy in Two Children,” Pediatric Dermatology, Vol. 23, No. 5, 2006, pp. 493-496.
[2] J. J. Crowly, A. Nikko, A. Varghese, et al., “Mycosis Fungoides in Young Patients: Clinical Characteristics and Outcome,” Journal of the American Academy of Dermatology, Vol. 38, No. 5, 1998, pp. 696-701. doi:10.1016/S0190-9622(98)70198-7
[3] S. E. Whitmore, et al., “Hypopigmented Mycosis Fungoides,” Archives of Dermatology, Vol. 130, No. 4, 1994, pp. 476-480. doi:10.1001/archderm.1994.01690040080012
[4] E. Tuyp, A. Burgoyne, T. Aitchison, et al., “A CaseControl Study of Possible Causative Factors in Mycosis Fungoides,” Archives of Dermatology, Vol. 123, No. 2, 1987, pp. 196-200. doi:10.1001/archderm.123.2.196
[5] Y. H. Kim, et al., “Long-Term Outcome of 525 Patients with Mycosis Fungoides and Sézary Syndrome,” Archives of Dermatology, Vol. 139, No. 7, 2003, pp. 857-866.
[6] A. Di Landro, L. Marchesi, L. Naldi, T. Motta and T. Cainelli, “A Case of Hypopigmented Mycosis Fungoides in a Young Caucasian Boy,” Pediatric Dermatology, Vol. 14, No. 6, 1997, pp. 449-452. doi:10.1111/j.1525-1470.1997.tb00687.x
[7] E. Sezer, T. Sezer, A. Senayli, D. Koseoglu and N. Filiz, “Hypopigmented Mycosis Fungoides in a Caucasian Child,” European Journal of Dermatology, Vol. 16, No. 5, 2006, p. 584.
[8] S. M. Breathnach, P. H. Mckee and N. P. Smith, “Hypopigmented Mycosis Fungoides: Report of Five Cases with Ultrastructural Observations,” British Journal of Dermatology, Vol. 106, No. 6, 1982, pp. 643-649. doi:10.1111/j.1365-2133.1982.tb11678.x
[9] D. J. Goldberg, R. A. Schinella and P. Kechijian, “Hypopigmented Mycosis Fungoides: Speculations about the Mechanism of Hypopigmentation,” The American Journal of Dermatopathology, Vol. 8, No. 4, 1986, pp. 326-330. doi:10.1097/00000372-198608000-00009
[10] J. T. Al-Ratrout, M. Al-Nazer and N. A. Ansari, “Hypopigmented Mycosis Fungoides in a Twenty-Year-Old Saudi Woman with Fair Skin,” Indian Journal of Dermatology, Vol. 51, No. 2, 2006, pp. 115-117. doi:10.4103/0019-5154.26932
[11] L. El-Shabrawi-Caelen, L. Cerroni, L. J. Medeiros, T. H. McCalmont, “Hypopigmented Mycosis Fungoides: Frequent Expression of a CD8+ T-Cell Phenotype,” The American Journal of Surgical Pathology, Vol. 26, No. 4, 2002, pp. 450-457. doi:10.1097/00000478-200204000-00006
[12] A. Manzur and S. T. H. Zaid, “Hypopigmented Mycosis Fungoides in a 10-Year-Old Boy,” Dermatology Online Journal, Vol. 12, No. 6, 2006, p. 21.

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