Cardiac Mass and Hypertrophic Cardiomyopathy as Aggressive Presentation of Primary Cardiac Lymphoma: A Case Report


Primary cardiac lymphoma is very rare. This disease occurs mainly in immunocompromised patients and rarely in the immunocompetent. With the advent of echocardiogram, computed tomography and magnetic resonance imaging, more cases are being diagnosed ante-mortem although the prognosis still remains poor. These cardiac tumors provide unique diagnostic and therapeutic challenges. We present an interesting case of primary cardiac lymphoma diagnosed antemortem in an 81 year old immunocompetent female presenting as a large mass in the right atrium, right ventricle and encasing the right coronary artery; and asymmetric left ventricular hypertrophy, a variant of hypertrophic cardiomyopathy. Patient responded very well to chemotherapy with subsequent regression of the cardiac mass and ventricular hypertrophy.

Share and Cite:

M. Haran, E. Enakpene and A. Lodha, "Cardiac Mass and Hypertrophic Cardiomyopathy as Aggressive Presentation of Primary Cardiac Lymphoma: A Case Report," Journal of Cancer Therapy, Vol. 3 No. 3, 2012, pp. 183-186. doi: 10.4236/jct.2012.33026.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. M Sarjeant, J. Butany and R. J. Cusimano, “Cancer of the Heart: Epidemiology and Management of Primary Tumors and Metastases,” American Journal of Cardiovascular Drugs, Vol. 3, No. 6, 2003, pp. 407-421. doi:10.2165/00129784-200303060-00004
[2] H. Ikeda, et al., “Primary Lymphoma of the Heart: Case Report and Literature Review,” Pathology International, Vol. 54, No. 3, 2004, pp. 187-195. doi:10.1111/j.1440-1827.2003.01606.x
[3] A. Petrich, S. I. Cho and H. Billett, “Primary Cardiac Lymphoma: An Analysis of Presentation, Treatment, and Outcome Patterns,” Cancer, Vol. 117, No. 3, 2.11, pp. 581-589. doi:10.1002/cncr.25444
[4] K. Tanoue, et al., “Malignant Lymphoma with Various Cardiac Manifestations: A Case Report,” Journal of Cardiology, Vol. 40, No. 3, 2002, pp. 117-123.
[5] H. Kadhim, et al., “Cardiac Lymphoma Presenting as Concentric Pseudo-Hypertrophic Cardiomyopathy in a Previously Unrecognised Hiv Patient,” Pathology, Vol. 41, No. 7, 2009, pp. 706-709. doi:10.3109/00313020903306082
[6] Z. Frikha, et al., “Cardiac Tamponade and Paroxysmal Third-Degree Atrioventricular Block Revealing a Primary Cardiac Non-Hodgkin Large B-Cell Lymphoma of the Right Ventricle: A Case Report,” Journal of Medical Case Reports, Vol. 5, 2011, p. 433. doi:10.1186/1752-1947-5-433
[7] G. L. Ceresoli, et al., “Primary Cardiac Lymphoma in Immunocompetent Patients: Diagnostic and Therapeutic Management,” Cancer, Vol. 80, No. 8, 1997, pp. 1497-1506. doi:10.1002/(SICI)1097-0142(19971015)80:8<1497::AID-CNCR18>3.0.CO;2-0
[8] K. P. Cohoon, W. Howe and T. Mc Kiernan, “Primary Cardiac Diffuse, Large B-Cell Lymphoma in an Immunocompetent Patient,” The Journal of Invasive Cardiology, Vol. 20, No. 2, 2008, pp. E59-E60.
[9] J. J. Monsuez, et al., “Non-Hodgkin’s Lymphoma with Cardiac Presentation: Evaluation and Follow-Up with Echocardiography and MR Imaging,” European Heart Journal, Vol. 12, No. 3, 1991, pp. 464-467.
[10] L. Chalabreysse, et al., “Primary Cardiac Lymphoma in Immunocompetent Patients: A Report of Three Cases and Review of the Literature,” Virchows Archiv, Vol. 441, No. 5, 2002, pp. 456-461. doi:10.1007/s00428-002-0711-0
[11] E. M. Artal, et al., “Primary Cardiac Lymphoma: Presentation of Two Cases in Immunocompetent Patients,” Anales de Medicina Interna, Vol. 19, No. 12, 2002, pp. 629-631.
[12] P. W. Lee, et al., “Images in Cardiovascular Medicine. Diffuse Infiltration of Lymphoma of the Myocardium Mimicking Clinical Hypertrophic Cardiomyopathy,” Circulation, Vol. 113, No. 12, 2006, pp. e662-e664. doi:10.1161/CIRCULATIONAHA.105.576306
[13] C. S. Chim, et al., “Primary Cardiac Lymphoma,” American Journal of Hematology, Vol. 54, No. 1, 1997, pp. 79-83. doi:10.1002/(SICI)1096-8652(199701)54:1<79::AID-AJH13>3.0.CO;2-5
[14] R. Bambury, et al., “Primary Cardiac Lymphoma: Diagnostic Tools and Treatment Challenges,” Irish Journal of Medical Science, Vol. 180, No. 1, 2011, pp. 271-273. doi:10.1007/s11845-009-0446-x
[15] H. S. Cabin, et al., “Cardiac Lymphoma Mimicking Hypertrophic Cardiomyopathy,” American Heart Journal, Vol. 102, No. 3, 1981, pp. 466-468. doi:10.1016/0002-8703(81)90328-8
[16] A. F. Nascimento, G. L. Winters and G. S. Pinkus, “Primary Cardiac Lymphoma: Clinical, Histologic, Immunophenotypic, and Genotypic Features of 5 Cases of a Rare Disorder,” The American Journal of Surgical Pathology, Vol. 31, No. 9, 2007, pp. 1344-1350. doi:10.1097/PAS.0b013e3180317341
[17] J. M. Van Der Klooster, et al., “Asystole during Combination Chemotherapy for Non-Hodgkin’s Lymphoma: The Acute Tumor Lysis Syndrome,” The Netherlands Journal of Medicine, Vol. 56, No. 4, 2000, pp. 147-152. doi:10.1016/S0300-2977(99)00124-2

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.