Dermabond Protape (Prineo) for Wound Closure in Plastic Surgery

Abstract

Dermabond Protape (2-octyl-cyanoacrylate and pressure sensitive adhesive mesh; Prineo, Closure Medical Corporation) is a topical mesh and skin adhesive that forms a strong polymeric bond across opposed wound edges allowing the normal healing process to occur. No published studies have already compared the use of a topical mesh en skin adhesive in wound closure. This study evaluated the possible applications of a combined mesh-adhesive system in 100 plastic surgery operations (14 different surgical procedures) with a mean follow-up of 85.5 days. The rate of allergic reaction, infection, wound dehiscence and hypertrophic scar formation were recorded in relation to patient co-morbidities, medication and tobacco consumption. No technical restrictions were found during the Dermabond Protape application. The average time for the topical mesh and skin adhesive application was 2 minutes. The Dermabond protape was removed 7 through 10 days after the operation. Three patients (3/100 or 3%) reported an allergic reaction without increased scar formation. Hyper-inflammation in one or more wound areas with a micro-abscess were noted in 11 different patients probably due to polyglactin 910 (vicryl) sutures at their scheduled follow-up visit 1 week after their operation. Increased tissue inflammation and scar formation were found in these patients with hypertrophic scars in 1 patient (1/11 or 9.1%). One upper leg wound dehiscence was seen in a diabetes mellitus patient using corticosteroids. Two patients (2/100 or 2%) with a history of tobacco abuse showed a partial wound dehiscence after an abdominoplasty and a partial areola dehiscence after mamma reduction respectively (Table 2).

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M. P. J. Loonen and M. A. M. Depoorter, "Dermabond Protape (Prineo) for Wound Closure in Plastic Surgery," Modern Plastic Surgery, Vol. 2 No. 2, 2012, pp. 20-23. doi: 10.4236/mps.2012.22005.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] J. Quinn, G. Wells, T. Sutcliffe, et al., “A Randomized Trial Comparing Octylcyanoacrylate Tissue Adhesive and Sutures in the Management of Lacerations,” JAMA, Vol. 277, No. 19, 1997, pp. 1527-1530. doi:10.1001/jama.1997.03540430039030
[2] O. Laccourreye, R. Cauchois, L. EL Sharkawy, et al., “Octylcyanoacrylate (Dermabond) for Skin Closure at the Time of Head and Neck Surgery: A Longitudinal Prospective Study,” Annales de Chirurgie, Vol. 130, No. 10, 2005, pp. 624-630. doi:10.1016/j.anchir.2005.10.003
[3] A. Silvestri, C. Brandi, L. Grimaldi, et al., “Octyl-2-Cya noacrylate Adhesive for Skin Closure and Prevention of Infection in Plastic Surgery,” Aesthetic Plastic Surgery, Vol. 30, No. 6, 2006, pp. 695-699. doi:10.1007/s00266-006-0139-z
[4] N.C.B.I.-N.L.M.-N.I.H., “Service of the U.S. National Library of Medicine and the National Institutes of Health,” 2010. http://www.ncbi.nlm. nih.gov/pubmed
[5] S. Bhende, S. Rothenburger, D. Spangler, et al., “In Vitro Assessment of Microbial Barrier Properties of Dermabond Topical Skin Adhesive,” Surgical Infections, Vol. 3, No. 3, 2002, pp. 251-257. doi:10.1089/109629602761624216
[6] E. F. Switzer, R. C. Dinsmore and J.H. North Jr., “Subcuticular Closure versus Dermabond: A Prospective Randomized Trial,” American Journal of Surgery, Vol. 69, No. 5, 2003, pp. 434-436.
[7] A. W. Perry and M. Sosin, “Severe allergic reaction to Dermabond,” Aesthetic Surgery Journal, Vol. 29, No. 4, 2009, pp. 314-316. doi:10.1016/j.asj.2009.02.019
[8] C. M. Hivnor and M. L. Hudkins, “Allergic Contact Dermatitis after Postsurgical Repair with 2-Octylcyanoacrylate,” Archives of Dermatology, Vol. 144, No. 6, 2008, pp. 814-815. doi:10.1001/archderm.144.6.814
[9] K. M. Dunst, J. Auboeck, B. Zahel, B. Raffier, et al., “Extensive Allergic Reaction to a New Wound Closure Device (Prineo),” Allergy, 11 November 2009. (EPUB ahead of Print).

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