Characteristic Radiological and Histological Patterns of Fibrous Dysplasia and Ossifying Fibroma of the Jaws at University of Nairobi Dental Teaching Hospital


Objective: To characterize the diagnostic features of ossifying fibroma (OF) and fibrous dysplasia (FD) of the jaw bones. Study Design: A histopathological and radiological analysis with full clinical documentation. Setting: University of Nairobi Dental Teaching Hospital (UNDH). Study Population: All archival cases diagnosed as FD and OF from 1992-2006 were retrieved from the UNDH Oral Pathology Laboratory records. New cases were included as they pre-sented over a 6-month period from January to June 2007. Methodology: Information regarding the histological type of a fibro-osseous lesion (FOL) including the clinical features, demographic and radiographic data was documented for analysis; and comparison between pathological parameters and the final diagnosis was evaluated with the chi-square test. Results: FD lesions constituted 40 (27.2%) cases while 107 (72.8%) were OF. The age ranged from 1 - 72 years (mean = 24.19 ± SD 13 years). The differences in the gender distribution were not statistically significant. Radiographic analyses showed statistically significant differences between the appearances of the body (p = 0.012) and the margins (p = 0.003) of FD and OF. The microscopic differences between the two lesions were not statistically significant. Conclusion: Differentiation between FD and OF is only possible after critically analyzing the clinical, radiological and histological criteria.

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J. Moshy, E. Dimba, T. Ocholla and M. Chindia, "Characteristic Radiological and Histological Patterns of Fibrous Dysplasia and Ossifying Fibroma of the Jaws at University of Nairobi Dental Teaching Hospital," Surgical Science, Vol. 3 No. 4, 2012, pp. 189-193. doi: 10.4236/ss.2012.34036.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] F. Alawi, “Benign Fibro-Osseous Diseases of the Maxillofacial Bones. A Review and Differential Diagnosis,” American Journal of Clinical Pathology, Vol. 118, 2002, pp. S50-S70.
[2] C. A. Waldron, “Fibro-Osseous Lesions of the Jaws,” Journal of Oral and Maxillofacial Surgery, Vol. 51, No. 8, 1993, pp. 828-835. doi:10.1016/S0278-2391(10)80097-7
[3] D. S. Macdonald-Jankowsk, “Fibro-Osseous Lesions of the Face and Jaws,” Clinical Radiology, Vol. 59, No. 1, 2004, pp. 11-25.
[4] S. Toyosawa, M. Yuki, M. Kishino, Y. Ogawa, T. Ueda, S. Murakani, E. Konishi, S. Lida, M. Kogo, T. Komor and Y. Tomita, “Ossifying Fibroma vs. Fibrous Dysplasia of the Jaw: Molecular and Immunological Characterization,” Modern Pathology, Vol. 20, No. 3, 2007, pp. 389-396. doi:10.1038/modpathol.3800753
[5] L. C. M. Keijser, T. G. van Tienen, H. W. D. Schreuder, J. A. M. Lemmens, M. J. Pruszcynski and R. P. H. Veth, “Fibrous Dysplasia of Bone: Management and Outcome of 20 Cases,” Journal of Surgical Oncology, Vol. 76, No. 3, 2001, pp. 157-166. doi:10.1002/jso.1028
[6] L. Barnes, J. W. Eveson, P. Reichart and D. Sidransky, “World Health Organization Classification of Tumours Pathologyand Genetics of Head and Neck Tumours,” IARC Press, Lyon, 2005.
[7] R. B. Brannon and C. B. Fowler, “Benign Fibro-Osseous Lesions: A Review of Current Concepts,” Advances in Anatomic Pathology, Vol. 8, No. 3, 2001, pp. 126-143. doi:10.1097/00125480-200105000-00002
[8] P. J. Slootweg, “Lesions of the Jaws,” Histopathology, Vol. 54, No. 4, 2009, pp. 401-418. doi:10.1111/j.1365-2559.2008.03097.x
[9] C.-C. Chang, H.-Y. Hung, J. Y.-F. Chang, C.-H. Yu, Y.-P. Wang, B.-Y. Liu and C.-P. Chiang, “Central Ossifying Fibroma: A Clinicopathological Study of 28 Cases,” Journal of the Formosan Medical Association, Vol. 107, No. 4, 2008, pp. 288-294. doi:10.1016/S0929-6646(08)60089-3
[10] J. J. Sciubba, J. E. Fantasia and L. B. Kahn, Eds., “Fibro-Osseous Lesions. AFIP Atlas of Tumor Pathology. Tumors and Cysts of the Jaw,” 3rd Series, Fasc 29 Edition, Armed Forces Institute of Pathology, Washington DC, 1999.
[11] M. M. Cohen Jr. and R. E. Howell, “Etiology of Fibrous Dysplasia and McCune-Albright Syndrome,” International Journal of Oral and Maxillofacial Surgery, Vol. 28, No. 5, 1999, pp. 366-371. doi:10.1034/j.1399-0020.1999.285280512.x
[12] A. Sakamoto, Y. Oda, Y. Iwato and M. Tsuneyoshi, “A Comparative Study of Fibrous Dysplasis and Osteofibrous Dysplasia with Regard to Gsα Mutation at the Ang201codon. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Analysis of Paraffin Embedded Tissue,” Journal of Molecular Diagnostic, Vol. 2, No. 2, 2000, pp. 67-72. doi:10.1016/S1525-1578(10)60618-6
[13] X. H. Ye, “Radiologic Diagnosis and Differential Diagnosis of Fibrous Dysplasia of the Facial Bones,” Chinese Journal of Radiology, Vol. 23, No. 2, 1989, pp. 86-89.
[14] C. O. Ogunsalu, A. Lewis and L. Doonquah, “Benign Fibro-Osseous Lesions of the Jaw Bones in Jamaica: Analysis of 32 Cases,” Oral Diseases, Vol. 7, No. 3, 2001, pp. 155-162. doi:10.1034/j.1601-0825.2001.70304.x
[15] Y. Lu, X. Lei and Z. Zhou, “Radiologic Study of Ossifying Fibroma of the Facial and Jaw Bones,” Chinese Journal of Radiology, Vol. 30, No. 2, 1995, pp. 75-77.
[16] A. Barberi, S. Cappabianca and G. Collela, “Bilateral Cemento-Ossifying Fibroma of the Maxillary Sinus,” The British Journal of Radiology, Vol. 76, 2003, pp. 279-280.
[17] M. J. Alsharif, Z.-J. Sun, X.-M. Chen, S.-P. Wang and Y.-F. Zhao, “Benign Fibro-Osseous Lesions of the Jaws: A Study of 127 Chinese Patients and Review of the Literature,” International Journal of Surgical Pathology, Vol. 17, No. 2, 2009, pp. 122-134. doi:10.1177/1066896908318744
[18] M. Riminucci, B. Liu, A. Corsi, A. Shenker, A. M. Speigel, P. G. Robey and P. Bianco, “The Histopathology of Fibrous Dysplasia of Bone in Patients with Activating Mutations of the Gsα Gene: Sit Specific Patterns and Recurrent Histological Hallmarks,” Journal of Pathology, Vol. 187, No. 2, 1999, pp. 249-258. doi:10.1002/(SICI)1096-9896(199901)187:2<249::AID-PATH222>3.0.CO;2-J

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