Bizarre Parosteal Osteochondromatous Proliferation-Like Lesion Originating in Soft Tissue: Report of a Case


Many tumors are unique to the organs from which they arise. Over the last 20 years, however, most tumors that were thought to be primary in soft tissues (derived from the primitive mesenchyme) and thought not to have counterparts in bone, were found to, in fact, rarely arise as unique lesions from bone. Some examples include synovial sarcoma, rhabdomyosarcoma and leiomyosarcoma, to name but three. We now have begun to see the reverse with lesions that were initially thought to be unique to bone arising in soft tissue. While this has been well reported with osteosarcoma and Ewing's sarcoma, it has never been reported with Bizarre Parosteal Osteochondromatous Proliferation (BPOP), also known as Nora's lesion. This study explores the first reported case of a soft tissue lesion, with clinical, radiological and histopathological characteristics of BPOP.

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K. N. Jhala, S. Wei, R. R. Lopez-Ben and G. P. Siegal, "Bizarre Parosteal Osteochondromatous Proliferation-Like Lesion Originating in Soft Tissue: Report of a Case," Open Journal of Pathology, Vol. 2 No. 2, 2012, pp. 38-41. doi: 10.4236/ojpathology.2012.22008.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] G. Gruber, C. Giessauf, A. Leithner, M. Zacherl, H. Clar, K. Bodo and R. Windhager, “Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion): A Report of 3 Cases and a Review of the Literature,” Canadian Journal of Surgery, Vol. 51, No. 1, 2008, pp. 486-489.
[2] L. Abramovici and G. C. Steiner, “Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion): A Retrospective Study of 12 Cases, 2 Arising in Long Bones,” Human Pathology, Vol. 33, No. 12, 2002, pp. 1205-1210. doi:10.1053/hupa.2002.130103
[3] J. B. Bush, J. D. Reith and M. S. Meyer, “Bizarre Parosteal Osteochondromatous Proliferation of the Proximal Humerus: Case Report,” Skeletal Radiology, Vol. 36, No. 6, 2007, pp. 535-540. doi:10.1007/s00256-006-0236-8
[4] M. F. Meneses, K. K. Unni and R. G. Swee, “Bizarre Parosteal Osteochondromatous Proliferation of Bone (Nora’s Lesion),” The American Journal of Surgical Pathology, Vol. 17, No. 7, 1993, pp. 691-697. doi:10.1097/00000478-199307000-00006
[5] A. Mohammad, A. Kilcoyne, S. Blake and M. Phelan, “Second Toe Swelling: Nora’s Lesion or Glomus Tumour, Case Report and Literature Review,” IRISH Journal of Medical Science, 8 October 2009. doi:10.1007/s11845-009-0435-0
[6] E. Simon, N. Vedrine and J. F. Chassagne, “Bizarre Parosteal Osteochondromatous Proliferation or Nora’s Lesion,” Revue de Stomatologie et de Chirurgie Maxillofaciale, Vol. 110, No. 4, 2009, pp. 224-226. doi:10.1016/j.stomax.2009.06.006
[7] M. Nilsson, H. A. Domanski, F. Mertens and N. Mandahl, “Molecular Cytogenetic Characterization of Recurrent Translocation Breakpoints in Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion),” Human Pathology, Vol. 35, No. 9, 2004, pp. 1063-1069. doi:10.1016/j.humpath.2004.02.008
[8] M. Endo, T. Hasegawa, T. Tashiro, U. Yamaguchi, Y. Morimoto, F. Nakatani and T. Shinoda, “Bizarre Parosteal Osteochondromatous Proliferation with a t(1;17) Translocation,” Virchows Archiv, Vol.447, No. 1, 2005, pp. 99-102. doi:10.1007/s00428-005-1266-7
[9] I. J. Cohen, J. Issakov and S. Avigad, et al., “Synovial Sarcoma of Bone Delineated by Spectral Karyotyping,” Lancet, Vol. 350, No. 9092, 1997, pp. 1679-1680. doi:10.1016/S0140-6736(05)64278-X
[10] Z. Eduardo, N. Vania, P.-A. Antonio, M. Gebhardt, M. T. Hresko, P. Kleinman, K. E. Richkind and H. P. Kozakewich, “Distinct Chromosomal Rearrangements in Subungual (Dupuytren) Exostosis and Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion),” The American Journal of Surgical Pathology, Vol. 28, No. 8, 2004, pp. 1033-1039. doi:10.1097/01.pas.0000126642.61690.d6
[11] A. Sakamoto, S. Imamura, Y. Matsumoto, K. Harimaya, S. Matsuda, Y. Takahashi, Y. Oda and Y. Iwamoto, “Bizarre Parosteal Osteochondromatous Proliferation with an Inversion of Chromosome 7,” Skeletal Radiology, Vol. 40, No. 11, 2011, pp. 1487-1490. doi:10.1007/s00256-011-1173-8

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