Olive and Corn Oil Enriched Diets Changed the Phospholipid Fatty Acid Composition in Mice Liver after One-Thirds Hepatectomy

DOI: 10.4236/fns.2012.32035   PDF   HTML     4,126 Downloads   6,838 Views   Citations

Abstract

We examined the effect of dietary fats on the kinetics of liver regeneration after one-third partial hepatectomy (PH) in male Balb/c mice. Corn and olive supplemented diets were chosen as a model of n-6 and n-9 diets. Phospholipid fatty acids were determined by gas chromatography (GC) after previous fractionation by solid-phase extraction using aminopropyl (NH2) column, and data were analysed by nonparametric Kruskal-Wallis test. Diet enriched with corn and olive oil did not affect the balance of lipid disorders during liver regeneration after 1/3 PH. Desaturases activity direction has changed depending on the used diet. The key role in the alteration of the polar fatty acids profile at all stages of liver regeneration and examined dietary fats is played by activity of stearoyl-CoA desaturase (SCD).

Share and Cite:

J. Giacometti, A. Tomljanovic, C. Milin, M. Cuk and B. Stasic, "Olive and Corn Oil Enriched Diets Changed the Phospholipid Fatty Acid Composition in Mice Liver after One-Thirds Hepatectomy," Food and Nutrition Sciences, Vol. 3 No. 2, 2012, pp. 240-248. doi: 10.4236/fns.2012.32035.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] S. M. Mahler, P. A. Wilce and B. C. Shanley, “Studies of Regenerating Liver and Hepatoma Plasma Membranes-I. Lipid and Protein Composition,” International Journal of Biochemistry, Vol. 20, No. 6, 1988, pp. 605-611. doi:10.1016/0020-711X(88)90100-0
[2] S. M. Mahler, P. A. Wilce and B. C. Shanley, “Studies of Regenerating Liver and Hepatoma Plasma Membranes-II. Membrane Fluidity and Enzyme Activity,” International Journal of Biochemistry, Vol. 20, No. 6, 1982, pp. 613619. doi:10.1016/0020-711X(88)90101-2
[3] S. D. Clarke, M. K. Armstrong and D. B. Jump, “Dietary Polyunsaturated Fats Uniquely Suppress Rat Liver Fatty Acid Synthase and S14 mRNA Content,” Journal of Nutrition, Vol. 120, No. 2, 1990, pp. 225-231.
[4] S. D. Clarke and D. B. Jump, “Dietary Polyunsaturated Fatty Acid Regulation of Gene Transcription,” The Annual Review of Nutrition, Vol. 14, No. 1, 1994, pp. 83-98. doi:10.1146/annurev.nu.14.070194.000503
[5] D. B. Jump, “Fatty Acid Regulation of Gene Transcription,” Critical Reviews in Clinical Laboratory Sciences, Vol. 41, No. 1, 2004, pp. 41-78. doi:10.1080/10408360490278341
[6] J. Giacometti, C. Milin, M. Tota, M. Cuk and B. Radosevic-Stasic, “Incorporation of Fatty Acids into Tissue Phospholipids in Mice Fed with Diets Rich in n-9 and n-6 Fatty Acids,” Croatica Chemica Acta, Vol. 78, No. 3, 2005, pp. 397-404.
[7] N. Fausto, “Liver Regeneration,” Journal of Hepatology, Vol. 32, Sup. 1, 2000, pp. 19-31. doi:10.1016/S0168-8278(00)80412-2
[8] P. S. Satdarshan Monga, P. Pediaditakis, K. Mule, D. Beer Stolz and G. K. Michalopoulos, “Changes in WNT/Catenin Pathway during Regulated Growth in Rat Liver Regeneration,” Hepatology, Vol. 33, No. 5, 2001, pp. 1098-1109. doi:10.1053/jhep.2001.23786
[9] J. Kountouras, P. Boura and N. Lygidakis, “Liver Regeneration after Partial Hepatectomy,” Hepatogastroenterology, Vol. 48, 2001, pp. 556-562.
[10] EEC Directive 2568, No. L248, 1991. http://eur-lex.europa.eu/LexUriServ/site/en/consleg/1991/R/01991R2568-20031101-en.pdf
[11] J. Folch, M. Lees and G. H. S. Stanley, “A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues,” Journal of Biological Chemistry, Vol. 226, 1957, pp. 497-509.
[12] J. Giacometti, A. Milosevic and C. Milin, “Gas Chromatographic Determination of Fatty Acids Contained in Different Lipid Classes after Their Separation by SolidPhase Extraction,” Journal of Chromatography A, Vol. 976, No. 1-2, 2002, pp. 47-54. doi:10.1016/S0021-9673(02)01159-7
[13] M. M. Markiewski, R. A. DeAngelis and J. D. Lambris, “Liver Inflammation and Regeneration: Two Distinct Biological Phenomena or Parallel Pathophysiologic Processes?” Molecular Immunology, Vol. 43, No. 1-2, 2006, pp. 45-56. doi:10.1016/j.molimm.2005.06.019
[14] R. Taub, “Liver Regeneration: From Myth to Mechanism,” Nature Reviews Molecular Cell Biology, Vol. 5, No. 10, 2004, pp. 836-847. doi:10.1038/nrm1489
[15] A. Yusuf, E. Laconi, P. M. Rao, S. Rajalakshmi and D. S. R. Sarma, “The Effect of 1/3 Partial Hepatectomy on the Growth of Glutathione S-Transferase Positive Foci,” Carcinogenesis, Vol. 20, No. 6, 1999, pp. 1143-1145. doi:10.1093/carcin/20.6.1143
[16] J. P. Carreau, P. Mazliak and D. Frommel, “Stearoyl-CoA Desaturation Capacity of the Rat Liver during Regenaration after Partial Hepatectomy,” International Journal of Biochemistry, Vol. 13, No. 6, 1981, pp. 765-767. doi:10.1016/0020-711X(81)90050-1
[17] I. M. Cristea and M. D. Esposti, “Membrane Lipids and Cell Death: On Overview,” Chemistry and Physics of Lipids, Vol. 129, No. 2, 2004, pp. 133-160. doi:10.1016/j.chemphyslip.2004.02.002
[18] I. Rusyn, C. A. Bradham, L. Cohn, R. Schoonhoven, J. A. Swenberg, D. A. Brenner, et al., “Corn Oil Rapidly Activates Nuclear Factor-?B in Hepatic Kupffer Cells by Oxidant-Dependent Mechanisms,” Carcinogenesis, Vol. 20, No. 11, 1999, pp. 2095-2100. doi:10.1093/carcin/20.11.2095
[19] D. B. Jump and S. D. Clarke, “Regulation of Gene Expression by Dietary Fat,” The Annual Review of Nutrition, Vol. 19, 1999, pp. 63-90. doi:10.1146/annurev.nutr.19.1.63
[20] C. W. Miller and J. M. Ntambi, “Peroxisome Proliferators Induce Mouse Liver Stearoyl-CoA Desaturase 1 Gene Expression,” Proceedings of the National Academy of Sciences of the USA, Vol. 93, No. 18, 1996, pp. 94439448. doi:10.1073/pnas.93.18.9443
[21] W. S. He, T. Y. Nara and M. T. Nakamura, “Delayed Induction of Delta-6 and Delta-5 Desaturases by a Peroxisome Proliferator,” Biochemical and Biophysical Research Communications, Vol. 299, No. 5, 2002, pp. 832838. doi:10.1016/S0006-291X(02)02743-2
[22] J. D. Horton, J. L. Goldstein and M. S. Brown, “SREBPs: Activators of the Complete Program of Cholesterol and Fatty Acid Synthesis in the Liver,” The Journal of Clinical Investigation, Vol. 109, No. 9, 2002, pp. 1125-1131. doi:10.1172/JCI200215593
[23] D. E. Tabor, J. B. Kim, B. M. Spiegelman and P. A. Edwards, “Identification of Conserved Cis-Elements and Transcription Factors Required for Sterol-Regulated Transcription of Stearoyl-CoA Desaturase 1 and 2,” Journal of Biological Chemistry, Vol. 274, 1999, pp. 20603-20610. doi:10.1074/jbc.274.29.20603
[24] G. Liang, J. Yang, J. D. Horton, R. E. Hammer, J. L. Goldstein and M. S. Brown, “Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-Binding Protein-1c,” Journal of Biological Chemistry, Vol. 277, 2002, pp. 9520-9528. doi:10.1074/jbc.M111421200
[25] T. Matsuzaka, H. Shimano, N. Yahagi and M. AmemiyaKudo, T. Yoshikawa, A. H. Hasty, et al., “Dual Regulation of Mouse ?5and ?6-Desaturase Gene Expression by SREBP-1 and PPAR?,” Journal of Lipid Research, Vol. 43, No. 1, 2002, pp. 107-114.
[26] T. Y. Nara, W. S. He, C. Tang, S. D. Clarke and M. T. Nakamura, “The E-Box Like Sterol Regulatory Element Mediates the Suppression of Human Delta-6 Desaturase Gene by Highly Unsaturated Fatty Acids,” Biochemical and Biophysical Research Communications, Vol. 296, No. 1, 2002, pp. 111-117. doi:10.1016/S0006-291X(02)00851-3

  
comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.