Trace Element Levels in Urban Ghanaian Pregnant Women

DOI: 10.4236/ojog.2020.10110149   PDF   HTML   XML   44 Downloads   103 Views  

Abstract

The trace elements used in the study are zinc, copper, selenium and iron, these have been implicated in various reproductive events. Maternal trace elements intake and their concentration are important for maternal and fetal well-being; however, data is insufficient in Ghanaian pregnant women. Especially, their concentration according to the pregnancy course (1st, 2nd, and 3rd trimester) should be determined, which may provide fundamental data of this issue. The maternal blood levels of four trace elements: zinc, copper, selenium and iron, were determined according to the gestational age in Ghanaian pregnant women. Blood samples were taken from 150 pregnant women (50 for each trimester) and 50 non-pregnant women (control). Concentration of four trace elements was measured using Flame Atomic Absorptive Spectrophotometer. The data (mean ± SD; ug/L) was as follows: in the order of control, 1st, 2nd, and 3rd trimester. 1) For zinc, 313 ± 211, 101 ± 92, 66 ± 63, and 443 ± 321. 2) For copper, 345 ± 261, 1349 ± 418, 1507 ± 388, and 1811 ± 344. 3) For selenium, 99 ± 25, 56 ± 17, 163 ± 38, and 261 ± 84. 4) For iron, 43.2 ± 15.2, 27.3 ± 15.7, 28.7 ± 17.2, and 40.5 ± 17 ug/L. Although each trace element showed various/specific concentrations according to the gestational age, overall tendency was a decline at 1st and 2nd trimester, and increase at 3rd trimester. The latter may be due to the introduction of supplementation. These data may be of use to consider maternal nutritional status in this area. Objective: To estimate the levels of zinc, copper, iron and selenium in pregnancy. Subjects were recruited from the Osu Maternity Home (OMH).

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Appiah, E. and Asare, G. (2020) Trace Element Levels in Urban Ghanaian Pregnant Women. Open Journal of Obstetrics and Gynecology, 10, 1658-1668. doi: 10.4236/ojog.2020.10110149.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Pathak, P. and Kapil, U. (2004) Role of Trace Elements Zinc, Copper and Magnesium during Pregnancy and Its Outcome. Indian Journal of Pediatrics, 71, 1003-1005.
https://doi.org/10.1007/BF02828116
[2] WHO (1996) Trace Elements in Human Nutrition and Health. WHO, Geneva, 72-104.
[3] Failla, M.L. (2003) Trace Elements and Host Defense: Recent Advances and Continuing Challenges. Journal of Nutrition, 133, 1443S-1447S.
https://doi.org/10.1093/jn/133.5.1443S
[4] King, J.C. (2000) Physiology of Pregnancy and Nutrient Metabolism. The American Journal of Clinical Nutrition, 71, 1218-1225.
https://doi.org/10.1093/ajcn/71.5.1218s
[5] Scheplyagina, L.A. (2005) Impact of the Mother’s Deficiency on the Woman’s and the Newborn’s Health Status. Journal of Trace Elements in Medicine and Biology, 19, 29-35.
https://doi.org/10.1016/j.jtemb.2005.07.008
[6] Siassakos, D. and Wardle, P. (2007) Polycystic Ovary Syndrome and Pregnancy Outcome: Red Herring or Red Flag? The International Journal of Gynecology & Obstetrics, 114, 922-932.
https://doi.org/10.1111/j.1471-0528.2007.01418.x
[7] Baig, S., Hasnian, N.U. and Ud-Din, Q. (2003) Studies on Zn, Cu, Mg, Ca and Phosphorous in Maternal and Cord Blood. Journal of Pakistan Medical Association, 53, 417.
[8] Barasi, M.E. (1997) Human Nutrition: A Health Perspective. Oxford University Press, New York, 187-189.
[9] Arnaud, J., Prual, A., Freziosi, et al. (1993) Effect of Iron Supplementation during Pregnancy on Trace Elements (Cu, Se, Zu) Concentrations in Serum and Breast Milk from Nigerian Woman. Annals of Nutrition and Metabolism, 37, 262-271.
https://doi.org/10.1159/000177776
[10] Al-Bader, A., Hussain, T., Al-Mosawi, M., Otaibi, M., Abul, H., Khalifa, D., et al. (1997) Serum Zinc and Copper Concentrations in Pregnant Women from Kuwait. The Journal of Trace Elements in Experimental Medicine, 10, 209-215.
https://doi.org/10.1002/(SICI)1520-670X(1997)10:4<209::AID-JTRA1>3.0.CO;2-4
[11] Widdowson, E.M., Dauncey, J. and Shaw, J.L.C. (1974) Trace Elements in Foetal and Early Postnatal Development. Proceedings of the Nutrition Society, 33, 275-284.
https://doi.org/10.1079/PNS19740050
[12] Beard, J.L. (2000) Effectiveness and Strategies of Iron Supplementation during Pregnancy. American Journal of Clinical Nutrition, 71, 1288s-1294s.
https://doi.org/10.1093/ajcn/71.5.1288s
[13] Georgieff, M.K., Berry, S.A., Wobken, J.K., Welle, J., Burdo, J.R., et al. (2000) Identification and Localization of Divalentmetal Transporter-1 (DMT-1) in Term Human Placenta. Placenta, 21, 799-804.
https://doi.org/10.1053/plac.2000.0566
[14] Bergamaschi, G., Bergamaschi, P., Carlevati, S. and Cazzola, M. (1990) Transferrin Receptor Expression in the Human Placenta. Haematologica, 75, 220-223.
[15] Mast, A.E., Blinder, M.A., Lu, Q., et al. (2002) Clinical Utility of the Reticulocyte Hemoglobin Content in the Diagnosis of Iron Deficiency. Blood, 99, 1489-1491.
https://doi.org/10.1182/blood.V99.4.1489
[16] Ghio, A.J., Carter, J.D., Richards, J.H., et al. (2003) Iron and Iron-Related Proteins in the Lower Respiratory Tract of Patients with Acute Respiratory Distress Syndrome. Critical Care Medicine, 31, 395-400.
https://doi.org/10.1097/01.CCM.0000050284.35609.97
[17] WHO/FAO/IAEA (1996) Trace Elements in Human Nutrition and Health. World Health Organisation, Geneva.
[18] Zachara, B.A., Wardak, C., Didkowski, W., Maciag, A. and Marchaluk, E. (1993) Changes in Blood Selenium and Glutathione Concentrations and Glutathione Peroxidase Activity in Human Pregnancy. Gynecologic and Obstetric Investigation, 35, 12-17.
https://doi.org/10.1159/000292655
[19] Ferrer, E., Algeria, A., Barabara, R., Farre, R., Largarda, M.J., et al. (1999) Whole Blood Selenium Content in Pregnant Women. Science of the Total Environment, 227, 139-143.
https://doi.org/10.1016/S0048-9697(99)00008-X

  
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