Journal of Biomedical Science and Engineering

Volume 12, Issue 9 (September 2019)

ISSN Print: 1937-6871   ISSN Online: 1937-688X

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Correlating Combined Features of Amino Acid and Protein with Crystallization Propensity of Proteins from Mycobacterium tuberculosis

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DOI: 10.4236/jbise.2019.129034    385 Downloads   970 Views  Citations
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ABSTRACT

Since a decade ago, both protein and amino acid features have been correlated with crystallization propensity of proteins in order to develop methods to predict whether a protein can be crystallized. In this continuing study, each of three features combining features of amino acid and protein, was correlated with the crystallization propensity of proteins from Mycobacterium tuberculosis using logistic and neural network models. The results showed that two combined features, amino acid distribution probability and future composition, had good predictions on whether a protein would be crystallized in comparison with the predictions obtained from each of 531 amino acid features. The results obtained from the third combined feature, amino acid pair predictability, demonstrated the trend of crystallization propensity in proteins from Mycobacterium tuberculosis.

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Yan, S. and Wu, G. (2019) Correlating Combined Features of Amino Acid and Protein with Crystallization Propensity of Proteins from Mycobacterium tuberculosis. Journal of Biomedical Science and Engineering, 12, 427-442. doi: 10.4236/jbise.2019.129034.

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