It is argued that in some zones of the Northern Apennines, in particular the Rimini-Ancona thrust system, the Romagna Apennines and the Alta Valtiberina trough, the probability of major earthquakes is now higher than in other Apennine zones. This hypothesis is suggested by the comparison of the present short-term kinematics of the Romagna-Marche-Umbria wedge in the Northern Apennines, deduced by the distribution of major shocks in the last tens of years, with the previous repeated behavior of the same wedge, evidenced by the distribution of major earthquakes in the last seven centuries. The seismotectonics of the Apennine region here considered is closely connected with the larger context that involves the progressive migration (from south to north) of seismicity along the peri-Adriatic zones. The information provided by this study can be used to better manage the resources for prevention in Italy.