Author(s)

Chunjiao Song

Medical Research Center, Shaoxing People’s Hospital/Shaoxing Hospital of Zhejiang University, Shaoxing, China.

Organisms evolved into different species to adapt to the environment according to the laws of Darwinian evolution. In a single life, prostate cancer cells can also evolve into tumor stem cells to adapt to the microenvironment, such as different chemotherapeutic drugs. These cancer cells become an unrestricted growth group relatively independent of the individual. The present review attempts to establish evidence that prostate cancer cells may survive by hormonotherapy and chemotherapy by gene amplification, mutation, and alternative splicing. Simultaneously, novel treatment strategies have been cited and evaluated, avoiding the resistance mechanisms.

Prostate Cancer, Androgen Receptor, Tumor Microenvironment, Darwinian Selection

Song, C. (2017) Darwinian Selection in Prostate Cancer and Medical Treatment. International Journal of Clinical Medicine, 8, 353-367. doi: 10.4236/ijcm.2017.86033.