Revision on the Recent Diagnostic Strategies of Fungal Infections - Open Journal of Medical Microbiology

OJMM > Vol.7 No.1, March 2017

Open Journal of Medical Microbiology

Volume 7, Issue 1 (March 2017)

ISSN Print: 2165-3372 ISSN Online: 2165-3380

Google-based Impact Factor: 1.15 Citations

Revision on the Recent Diagnostic Strategies of Fungal Infections ()

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Download as PDF (Size: 682KB) PP. 29-40

DOI: 10.4236/ojmm.2017.71003 4,242 Downloads 7,852 Views Citations

Author(s)

Amina Mostafa Abd El-Aal¹, Noha El-Mashad^1*, Al-Shaymaa Nasr Mohamed²

Affiliation(s)

¹Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
²Department of Clinical Pathology, Aga Central Hospital, Mansoura, Egypt.

ABSTRACT

Many invasive fungal diseases have no characteristic signs or symptoms, and may give negative blood cultures; therefore, clinician may decide to start empirical antifungal therapy particularly in high risk patient (e.g., hematopoietic stem cell transplant, solid organ transplant, and AIDS patients). This increases the incidence of appearance of resistant fungal strains to antifungal drugs. Traditional methods for diagnosis such as wet mount examination and microbiological cultures remain the gold standard methods for fungal disease diagnosis. However, they are time-consuming, insensitive, and have a limited impact on clinical decision-making. Significant progress has recently achieved in diagnostic tools of fungal disease. Antigen and antibody based assays, molecular techniques, and MALDI TOF spectrometry technique and nanotechnology offer more rapid, sensitive and accurate results.

KEYWORDS

Fungal Infections, Conventional Diagnostic Techniques, Mannan, MALDI-TOF MS, Molecular Diagnostic Techniques

Share and Cite:

El-Aal, A. , El-Mashad, N. and Mohamed, A. (2017) Revision on the Recent Diagnostic Strategies of Fungal Infections. Open Journal of Medical Microbiology, 7, 29-40. doi: 10.4236/ojmm.2017.71003.

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