Author(s)

Hiroaki Nishikawa^1*, Ayaka Saito², Akiko Miyake³, Yuichiro Tashiro³, Yoshiya Hashimoto⁴

¹Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan.
²Graduate School of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan.
³Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Japan.
⁴Department of Biomaterials, Osaka Dental University, Hirakata, Japan.

To increase the biocompatibility of hydroxyapatite (HA), Ca₁₀(PO₄)₆(OH)₂, the Sr substitution of Ca into the HA structure was effected to yield Ca_10-xSr_x(PO₄)₆(OH)₂(Sr-HA). For medical and dental applications, it is important that Sr-HA is prepared as a thin film so that the Sr fully substitutes the Ca sites in the HA structure and does not form segregated impurities consisting of Sr compounds. If the segregated Sr forms different amounts of different impurities, the dissolution of the Sr into the living body will not be reproducible across different samples. To confirm the Sr substitution into the Ca site in the HA structure, the systematic variation in the lattice constants of the Sr-HA with Sr content was evaluated as the first step. The a- and c-axis lengths were found to exhibit a linear relationship with the Sr content for six samples with different Sr contents, indicating that the prepared Sr-HA thin films likely possessed partial Sr substitution into the Ca sites of the HA structure. This result is an important first step in the accurate evaluation of the biological effects of Sr-HA thin films.

Sr Substituted Hydroxyapatite, X-Ray Diffraction, Lattice Constant, Pulsed Laser Deposition Technique

Nishikawa, H. , Saito, A. , Miyake, A. , Tashiro, Y. and Hashimoto, Y. (2017) Systematic Relationship between Sr Content and the Lattice Constants in Sr Substituted Hydroxyapatite Thin Films. Journal of Crystallization Process and Technology, 7, 1-10. doi: 10.4236/jcpt.2017.71001.