Author(s)

Kenya Murase

Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

Our purpose in this study was to present three methods for estimating specific loss power (SLP) in magnetic hyperthermia with use of an alternating magnetic field (AMF) and magnetic nanoparticles (MNPs) and to compare the SLP values estimated by the three methods using simulation studies under various diameters of MNPs (D), amplitudes (H₀) and frequencies of AMF (f). In the first method, the SLP was calculated by solving the magnetization relaxation equation of Shliomis numerically (SLP₁). In the second method, the SLP was obtained by solving Shliomis’ relaxation equation using the complex susceptibility (SLP₂). The third method was based on Rosensweig’s model (SLP₃). The SLP₃ value changed largely depending on the magnetic field strength (H) in the Langevin parameter (§) and it became maximum (SLP₃^max) and minimum (SLP₃^min) when H was 0 and ±H₀, respectively. The relative difference between SLP₁ and SLP₂ was the largest and increased with increasing D and H₀, whereas that between SLP₁ and was the smallest and was almost constant regardless of D and H₀, suggesting that H in ξ should be taken as H₀ in estimating the SLP using Rosensweig’s model. In conclusion, this study will be useful for optimizing the parameters of AMF in magnetic hyperthermia and for the optimal design of MNPs for magnetic hyperthermia.

Magnetic Hyperthermia, Magnetic Nanoparticle, Specific Loss Power, Alternating Magnetic Field, Magnetization Relaxation

Murase, K. (2016) Methods for Estimating Specific Loss Power in Magnetic Hyperthermia Revisited. Open Journal of Applied Sciences, 6, 815-825. doi: 10.4236/ojapps.2016.612071.