Journal of Biomedical Science and Engineering

Volume 8, Issue 10 (October 2015)

ISSN Print: 1937-6871   ISSN Online: 1937-688X

Google-based Impact Factor: 0.66  Citations  h5-index & Ranking

Large Deformation Characterization of Porcine Thoracic Aortas: Inverse Modeling Fitting of Uniaxial and Biaxial Tests

HTML  XML Download Download as PDF (Size: 3745KB)  PP. 717-732  
DOI: 10.4236/jbise.2015.810069    5,007 Downloads   6,057 Views  Citations

ABSTRACT

The elastic behavior of arteries is nonlinear when subjected to large deformations. In order to measure their anisotropic behavior, planar biaxial tests are often used. Typically, hooks are attached along the borders of a square sample of arterial tissue. Cruciform samples clamped with grips can also be used. The current debate on the effect of different biaxial test boundary conditions revolves around the uniformity of the stress distribution in the center of the specimen. Uniaxial tests are also commonly used due to simplicity of data analysis, but their capability to fully describe the in vivo behavior of a tissue remains to be proven. In this study, we demonstrate the use of inverse modeling to fit the material properties by taking into account the non-uniform stress distribution, and discuss the differences between the three types of tests. Square and cruciform samples were dissected from pig aortas and tested equi-biaxially. Rectangular samples were used in uniaxial testing as well. On the square samples, forces were applied on each side of edge sample attached with hooks, and strains were measured in the center using optical tracking of ink dots. On the cruciform and rectangular samples, displacements were applied on grip clamps and forces were measured on the clamps. Each type of experiment was simulated with the finite element method. The parameters of the Mooney-Rivlin constitutive model were adjusted with an optimization algorithm so that the simulation predictions fitted the experimental results. Higher stretch ratios (>1.5) were reached in the cruciform and rectangular samples than in the square samples before failure. Therefore, the nonlinear behavior of the tissue in large deformations was better captured by the cruciform biaxial test and the uniaxial test, than by the square biaxial test. Advantages of cruciform samples over square samples include: 1) higher deformation range; 2) simpler data acquisition and 3) easier attachment of sample. However, the nonuniform stress distribution in cruciform samples requires the use of inverse modeling adjustment of constitutive model parameters.

Share and Cite:

Delgadillo, J. , Delorme, S. , Thibault, F. , DiRaddo, R. and Hatzikiriakos, S. (2015) Large Deformation Characterization of Porcine Thoracic Aortas: Inverse Modeling Fitting of Uniaxial and Biaxial Tests. Journal of Biomedical Science and Engineering, 8, 717-732. doi: 10.4236/jbise.2015.810069.

Cited by

[1] A COUPLED EXPERIMENTAL AND NUMERICAL APPROACH TO CHARACTERIZE THE ANISOTROPIC MECHANICAL BEHAVIOR OF AORTIC TISSUES
2020
[2] Large-deformation strain energy density function for vascular smooth muscle cells
2020
[3] Identification of Material Parameters of a Hyper-Elastic Body With Unknown Boundary Conditions
2018
[4] Eksperimentalno određivanje utjecaja krioprezervacije na mehanička svojstva svinjskih aorti
2018
[5] Ispitivanje mehaničkoga ponašanja svinjskih aorti pri jednoosnom statičkom vlačnom opterećenju
2017
[6] Biaxial quantification of passive porcine myocardium elastic properties by region
2017
[7] Integrated experimental and numerical comparison of different approaches for planar biaxial testing of a hyperelastic material
Advances in Materials Science and Engineering, 2016
[8] Deformaciones plásticas de matrices de submucosa intestinal porcina y su efecto en la orientación de las fibras de colágeno presentes en la matriz
2016

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.