Solventless Organic Reactive Crystallization at Mild Conditions - Advances in Chemical Engineering and Science

ACES > Vol.5 No.4, October 2015

Advances in Chemical Engineering and Science

Volume 5, Issue 4 (October 2015)

ISSN Print: 2160-0392 ISSN Online: 2160-0406

Google-based Impact Factor: 1.22 Citations

Solventless Organic Reactive Crystallization at Mild Conditions ()

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DOI: 10.4236/aces.2015.54047 4,505 Downloads 5,681 Views Citations

Author(s)

Masaaki Yokota, Norihito Doki, Hiroyuki Akagaki

Affiliation(s)

Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan.

ABSTRACT

Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.

KEYWORDS

Reaction, Crystallization, Polymorphism, Dehydration Condensation

Share and Cite:

Yokota, M. , Doki, N. and Akagaki, H. (2015) Solventless Organic Reactive Crystallization at Mild Conditions. Advances in Chemical Engineering and Science, 5, 461-464. doi: 10.4236/aces.2015.54047.

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