Journal of Biosciences and Medicines

Volume 3, Issue 10 (October 2015)

ISSN Print: 2327-5081   ISSN Online: 2327-509X

Google-based Impact Factor: 0.51  Citations  

Reishi Mushroom Attenuates Hepatic Inflammation and Fibrosis Induced by Irradiation Enhanced Carbon Tetrachloride in Rat Model

HTML  XML Download Download as PDF (Size: 1310KB)  PP. 24-38  
DOI: 10.4236/jbm.2015.310004    3,819 Downloads   5,152 Views  Citations


This work was undertaken to establish a new experimental model of hepatic fibrosis by gamma irradiation and CCl4 and to study the hepatoprotective effect of Reishi Mushroom (RM) against hepatic fibrosis induced in that model. Our results revealed that oral co-administration of 110 mg/kg RM by gavage to fibrotic rats offered an obvious hepatic protection as assured by the significant decrement in ALT and AST, HP content, MDA and NO levels with elevation of the antioxidant enzymes activities. The levels of TGF-β, TNF-α, HO-1 and type-1 collagen and their m-RNA expression were markedly declined as compared with those of fibrotic rats. Microscopical examination revealed that the exposure of rats to radiation aggravated the effect of CCl4 causing extensive collagen deposition and marked pseudolobulation of the hepatic parenchyma indicative of bridging fibrosis. While, oral co-administration of RM obviously improved the state of steatosis and apparently suppressed hepatic fibrogenesis.

Share and Cite:

Shawi, O. , El-Rahman, S. and Hameed, M. (2015) Reishi Mushroom Attenuates Hepatic Inflammation and Fibrosis Induced by Irradiation Enhanced Carbon Tetrachloride in Rat Model. Journal of Biosciences and Medicines, 3, 24-38. doi: 10.4236/jbm.2015.310004.

Cited by

[1] Protective effect of Acrocarpus fraxinifolius Extract against Hepatic Fibrosis Induced by Gamma Irradiation and Carbon Tetrachloride in Albino Rats
Shawi, HAS El-Nashar… - … Journal of Radiation …, 2022
[2] Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma
deen, RA Nagy… - Egyptian Journal of …, 2022
[3] The Beneficial Effect of Nanostructured Oligochitosan against Gamma Irradiation and/or Carbon Tetrachloride-Induced Hepatic Injury in Rats
[4] Comparative study on the effect of low intensity laser and growth factors on stem cells used in experimentally-induced liver fibrosis in mice
Arab Journal of Gastroenterology, 2017
[5] Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome
Canadian Journal of Physiology and Pharmacology, 2017
[6] Phytochemical Investigation, Antitumor Activity, and Hepatoprotective Effects of Acrocarpus fraxinifolius Leaf Extract
[7] Effects of anti-oxidative and cholesterol lowering capacities of selected edible-medicinal mushrooms towards amelioration of alzheimer's disease/Mohammad Azizur …
[8] Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt–β-catenin signaling
Biochemistry and Cell Biology, 2016

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.