Author(s)

Deniz Gökalp, Senay Arıkan, Mustafa Yakut, Yekta Tüzün, Alparslan Kemal Tuzcu, Mithat Bahçeci, Senay Arikan, İrfan Soykan

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AIM: To determine the prevalence of celiac disease related autoantibodies in patients with type 1 and 2 diabetes mellitus (DM), and to compare these results with the general population. METHODS: In total, 137 consecutive patients with type 1 DM, 172 with type 2 DM and 113 age-sex matched control subjects were included into the study. Antigliadin-autoantibodies (AGA) IgG and IgA, and endomysial-antibodies(EMA) IgG and IgA antibodies were determined. Patients who were positive for one or more were offered a gastroduodenoscopic examination. RESULTS: AGA IgG positivity was detected in 38.7% (53/137) patients with type 1 DM in 26.2% (45/172) patients with type 2 DM and in 16.8% (19/113) control subjects (significant differences). AGA IgA positivity was detected in 24.8% (34/137) patients with type 1 DM, in 9.3% (16/172) patients with type 2 DM and in 3.5% (4/113) control subjects (significant differences). EMA IgG positivity was detected in 10.2% (14/137) patients with type 1 DM in 0.6% (1/176) patients with type 2 DM and 0.9% (1/113) control subjects (significant differences). EMA IgA positivity was detected in 11.7% (16/137) patients with type 1 DM in 0.6% (1/172) patients with type 2 DM and in none of control subjects. EMA IgA positivity was sig- nificantly higher in patients with type 1 DM as compared with patients with type 2 DM and controls. CONCLUSION: High prevalence of celiac disease at the diagnosis of type 1 DM is observed. Serological markers are useful for identifying celiac disease patients with type 1 DM.

Celiac Disease, Diabetes Mellitus, AGA Ig A, AGA Ig G, EMA Ig A, EMA Ig G

D. Gökalp, S. Arıkan, M. Yakut, Y. Tüzün, A. Tuzcu, M. Bahçeci, S. Arikan and İ. Soykan, "The Prevalence of Celiac Disease in Patients with Diabetes Mellitus—The Prevalence of Celiac Disease," International Journal of Clinical Medicine, Vol. 2 No. 3, 2011, pp. 201-205. doi: 10.4236/ijcm.2011.23033.