Author(s)

Andrei Ershov^*, Dmitry Nasledov, Igor Lagoda, Valery Shamanin

Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia.

Proceeding from natural amino acid L-asparagine and commercially available aldehydes a stereoselective synthesis was developed of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahy- dropyrimidine-4-carboxylic acids, potential antihypertensive drugs, inhibitors of the angiotensin converting enzyme.

Synthesis of (2S, 4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs

Ershov, A. , Nasledov, D. , Lagoda, I. and Shamanin, V. (2015) Synthesis of (2S,4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs. Journal of Materials Science and Chemical Engineering, 3, 7-12. doi: 10.4236/msce.2015.36002.