Author(s)

Lilian Di Toto Blessing¹, Florencia Budeguer¹, Juan Ramos⁴, Alicia Bardón^1,3, Sonia Diaz², Margarita Brovetto², Gustavo Seoane², Adriana Neske^1*

¹Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, Argentina.
²Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, Argentina.
³INQUINOA-CONICET, Tucumán, Argentina.
⁴Dpto de Química Orgánica, Fac de Química, UdelaR, Montevideo, Uruguay.

Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues on Spodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OH flanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Our study emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilic polar head groups. They are essential structural factors in the ACG that facilitate the intermolecular interaction that dehydrates the membrane and makes it potentially toxic against Spodoptera frugiperda.

Annonaceous Acetogenins, Polyphagous Lepidopteran, Toxicity, Nutritional Alterations

Di Toto Blessing, L. , Budeguer, F. , Ramos, J. , Bardón, A. , Diaz, S. , Brovetto, M. , Seoane, G. and Neske, A. (2015) Structural Factors of Annonaceous Acetogenins and Their Semisynthetic Analogues Related with the Toxicity on Spodoptera frugiperda. Journal of Agricultural Chemistry and Environment, 4, 56-61. doi: 10.4236/jacen.2015.42006.