Journal of Biophysical Chemistry

Volume 2, Issue 2 (May 2011)

ISSN Print: 2153-036X   ISSN Online: 2153-0378

Google-based Impact Factor: 1.25  Citations  

The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study

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DOI: 10.4236/jbpc.2011.22016    6,600 Downloads   11,701 Views  Citations
Author(s)

ABSTRACT

The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.

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Setzer, W. (2011) The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study. Journal of Biophysical Chemistry, 2, 135-136. doi: 10.4236/jbpc.2011.22016.

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