House Dust Mite Allergy Models—Reliability for Research of Airway Defensive Mechanisms - Open Journal of Molecular and Integrative Physiology

OJMIP > Vol.4 No.3, August 2014

Open Journal of Molecular and Integrative Physiology

Volume 4, Issue 3 (August 2014)

ISSN Print: 2162-2159 ISSN Online: 2162-2167

Google-based Impact Factor: 1 Citations

House Dust Mite Allergy Models—Reliability for Research of Airway Defensive Mechanisms ()

HTML

Download as PDF (Size: 2613KB) PP. 27-35

DOI: 10.4236/ojmip.2014.43004 4,805 Downloads 6,543 Views Citations

Author(s)

Tomas Buday, Jana Plevkova

Affiliation(s)

Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.

ABSTRACT

Extensive research of respiratory physiology and diseases of the airways and lungs provides better understanding of mechanisms of diseases and it is a source of new data with potential clinical application. The majority of the data in the field of airway defensive reflexes were obtained from guinea pig model, as the most convenient one. Neurophysiology and neuropharma-cology of the cough reflex—which is exclusively mediated by the vagus nerve, share close similarities between guinea pigs and humans. The models used to study pathological processes and their influence on airway-defensive reflexes use sensitization with ovalbumin—the protein from chicken egg, which does not mimic allergies within human respiratory system. House dust mites (HDM) (Dermatophagoides pteronyssius and Dermatophagoides farinae) represent frequent human aeroallergens, however the HDM models are used considerably less than ovalbumin models. The primary objective of this review is to focus on already validated models of HDM-induced airway diseases to see, whether some of them are suitable to study mechanisms of peripheral cough plasticity in a condition of HDM-induced pathological processes. The main purpose of future use and validation of HDM model is to produce higher ability to translate the results obtained in animal models to human cough research.

KEYWORDS

House Dust Mite, Allergy, Asthma, Animal Model, Ovalbumin, Cough

Share and Cite:

Buday, T. and Plevkova, J. (2014) House Dust Mite Allergy Models—Reliability for Research of Airway Defensive Mechanisms. Open Journal of Molecular and Integrative Physiology, 4, 27-35. doi: 10.4236/ojmip.2014.43004.

Cited by

[1]	Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5
	Molecular Immunology, 2024

[2]	Psychosocial impacts of coughing in public places during the COVID-19 pandemic: a cross-sectional study in the western region of Saudi Arabia
	Medical Journal of …, 2024

[3]	Short and dysfunctional telomeres protect from allergen‐induced airway inflammation
	2021

[4]	The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease
	2018

[5]	Investigation of the pathogenesis of influenza infection in asthma and COPD; potential therapeutic interventions
	2018

[6]	Attenuated airway hyperresponsiveness and mucus secretion in HDM exposed Igf1r‐deficient mice
	Allergy, 2017

[7]	Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice
	Allergy, 2017

[8]	The Hygiene Hypothesis, the Naïve Immune System and House Dust Mites
	2017

[9]	Revisão sistemática sobre modelos experimentais de asma aguda e crônica induzidos com extrato de ácaro da poeira doméstica
	2017

[10]	Attenuated airway hyperresponsiveness and mucus secretion in HDM‐exposed Igf1r‐deficient mice
	Allergy, 2017

[11]	Targeting PP 2A and proteasome activity ameliorates features of allergic airway disease in mice
	Allergy, 2017

[12]	Immunoregulatory therapies for inflammatory diseases
	2016

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies