Open Journal of Molecular and Integrative Physiology

Volume 4, Issue 2 (May 2014)

ISSN Print: 2162-2159   ISSN Online: 2162-2167

Google-based Impact Factor: 0.33  Citations  

Helical Repeats of Left-Handed DNA

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DOI: 10.4236/ojmip.2014.42003    7,423 Downloads   9,797 Views  Citations
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ABSTRACT

DNA is generally assumed as a right-handed double helix and Z-DNA is a special kind of left-handed DNA infrequently found in nature. However, the finding of a zero linking number topoisomer supports a hypothesis that the two strands of DNA are winding ambidextrously, rather than plectonemically. It logically leads to a notion that the left-handed DNA is as common as right-handed DNA and the amount of left-handed DNA in a positively supercoiled plasmid prevails that of the right-handed DNA. In this report, the helical repeat of left-handed DNA, 12 bp per turn, was determined by a new method. How the positively supercoiled DNA was generated in hyperthermophiles and why their DNA can withstand the extreme high temperature are answered from an alternative theory.

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Xu, Y. (2014) Helical Repeats of Left-Handed DNA. Open Journal of Molecular and Integrative Physiology, 4, 20-26. doi: 10.4236/ojmip.2014.42003.

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