Open Journal of Molecular and Integrative Physiology

Volume 4, Issue 2 (May 2014)

ISSN Print: 2162-2159   ISSN Online: 2162-2167

Google-based Impact Factor: 0.33  Citations  

Helical Repeats of Left-Handed DNA

HTML  Download Download as PDF (Size: 598KB)  PP. 20-26  
DOI: 10.4236/ojmip.2014.42003    7,423 Downloads   9,797 Views  Citations


DNA is generally assumed as a right-handed double helix and Z-DNA is a special kind of left-handed DNA infrequently found in nature. However, the finding of a zero linking number topoisomer supports a hypothesis that the two strands of DNA are winding ambidextrously, rather than plectonemically. It logically leads to a notion that the left-handed DNA is as common as right-handed DNA and the amount of left-handed DNA in a positively supercoiled plasmid prevails that of the right-handed DNA. In this report, the helical repeat of left-handed DNA, 12 bp per turn, was determined by a new method. How the positively supercoiled DNA was generated in hyperthermophiles and why their DNA can withstand the extreme high temperature are answered from an alternative theory.

Share and Cite:

Xu, Y. (2014) Helical Repeats of Left-Handed DNA. Open Journal of Molecular and Integrative Physiology, 4, 20-26. doi: 10.4236/ojmip.2014.42003.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.