Advances in Bioscience and Biotechnology

Volume 4, Issue 4 (April 2013)

ISSN Print: 2156-8456   ISSN Online: 2156-8502

Google-based Impact Factor: 1.18  Citations  h5-index & Ranking

Antibody research targeting Cathepsin S for cancer therapy

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DOI: 10.4236/abb.2013.44A003    4,202 Downloads   6,869 Views  Citations


Cathepsin S is a cysteine protease highly expressed in many type of cancers including colorectal, prostate, breast, and glioblastoma’s. It is involved in tumor progression through extracellular matrix remodeling. In recent years, antibody research specifically targeting Cathepsin S to block/inhibit tumorigenic effects were generated some positive preclinical data. This antagonistic antibody was demonstrating efficacy in multiple in vitro/in vivo cancer models both as a monotherapy and in combination with approved agents. This mini-review provides an overview of therapeutic antibody targeting Cathepsin S strategies in the last half decade, focusing on the rationale of cell-surface Cathepsin S targeted and their potential clinical application.

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Kwok, H. F. (2013) Antibody research targeting Cathepsin S for cancer therapy. Advances in Bioscience and Biotechnology, 4, 17-20. doi: 10.4236/abb.2013.44A003.

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