Tumour suppressor protein 53 (TP53 or simply p53) is a well known protein linked to apoptosis, cell signalling, cascading and several myriad functions in cells. Many diseases are linked to p53 though analysis show only 216 interaction partners. Whether p53 plays an important role in cardiovascular diseases (CVD) remains uncertain. Through this bioinformatical analysis, we propose that p53 might play a major role in CVD whilst being linked to Hypoxia and Lupus. There could be evidence by pull down assay studies. Whether its interactants play a role in CVD remains to be studied using experiments, though the interaction maps show possible affect on other diseases.