Author(s)

Mohammad Al-Masum^*, Linda Quinones

Department of Chemistry, Tennessee State University, Nashville, TN, USA.

Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.

Anandamide, Cross-Coupling, Microwave, Alcohol Amines

Al-Masum, M. and Quinones, L. (2024) A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst. International Journal of Organic Chemistry, 14, 128-134. doi: 10.4236/ijoc.2024.144008.