With the deepening of Belt and Road Initiative, more and more Chinese enterprises begin to go abroad. It will be extremely difficult for them to find vitality in the unfamiliar and changeable environment. Compared with the fluency and efficiency of relevant actions in China, the cultural barriers, organizational obstacle and multi-dimensional operations in overseas promotion often bring greater hidden dangers, which are directly influence business. Understanding and Matching local culture better and faster, establishing a talent pool suitable for enterprise development to reduce the risk caused by personnel flow, setting up an effective closed-loop development mechanism for talent, and ensuring the unity of standards and processes in multiple places have become the top priority of multinational Chinese enterprises in overseas talent management. This paper analyzes the difficulties and problems of multi-national Chinese enterprises, which focusing on lack of cultural empathy, rare reserve and high turnover rate of talents, and puts forward the reference and practice methods of talent strategy reform.