Sarcomatoid Carcinoma of the Mandible: A Case Report and Literature Review ()
Author(s)
Kenza Benali1,2,
Tayeb Kebdani1,2,
Khalid Hassouni1,2,
Sanaa El Majjaoui1,2,
Hanan El Kacemi1,2,
Noureddine Benjaafar1,2
ABSTRACT
Background: Sarcomatoid carcinoma is a rare biphasic malignancy with an epithelial
and mesenchymal component. Given its histological particularity, the diagnosis
of this tumor still represents a challenge for pathologists and surgeons.
Sarcomatoid carcinoma of the mandible is a very rare and aggressive entity. To
date, only sporadic cases have been reported in the literature. Aim: To
report a rare case of aggressive mandibular sarcomatoid carcinoma treated with
radical surgery and adjuvant chemoradiation, and discuss the related
literature. Case Report: We introduce a rare case of mandibular
sarcomatoid carcinoma occurring in a 34-year-old woman. Treatment consisted of
radical surgery and re-excision for positive margins, adjuvant radiation
therapy (66 Gy in 33 fractions in simultaneous integrated boost delivered using
Volumetric Modulated Arc Therapy) and Cisplatin-based concurrent chemotherapy.
The tumor displayed aggressive behavior and high metastatic potential, causing
tumour recurrence and extensive lung metastasis. Conclusion: Sarcomatoid
carcinoma of the mandible is an extremely rare malignant entity, with a high
tendency for local recurrence, distant metastasis. Treatment involves radical
surgery and adjuvant chemoradiation, although the outcome and prognosis might
be poor.
Share and Cite:
Benali, K. , Kebdani, T. , Hassouni, K. , Majjaoui, S. , Kacemi, H. and Benjaafar, N. (2022) Sarcomatoid Carcinoma of the Mandible: A Case Report and Literature Review.
Journal of Cancer Therapy,
13, 323-330. doi:
10.4236/jct.2022.136028.
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