Author(s)

Abdoul Karim Doumbia^1*, Pierre Togo¹, Mariam Maiga², Mohamed Elmouloud Cissé¹, Guédiouma Dembélé¹, Oumar Coulibaly¹, Karamoko Sacko¹, Belco Maiga¹, Djeneba Konaté¹, Abdou Diarra¹, Yakaria Coulibaly³, Fatoumata Léonie Diakité¹, Abdoul Aziz Diakité¹, Boubacar Togo¹, Check Bougadary Traore⁴, Adama Bah⁴

¹Department of Pediatrics at CHU Gabriel Touré, Bamako, Mali.
²Reference Health Center of the Municipality 6, Bamako, Mali.
³Pediatric Surgery Department of the Gabriel Touré CHU, Bamako, Mali.
⁴Pathological Anatomy and Cytology Department of the “Point G” CHU, Bamako, Mali.

Introduction: Nephroblastoma is the most common renal cancer in pediatrics. The aim of this study was to describe the epidemiological, clinical, histological characteristics and the immediate outcome of patients with nephroblastoma. Methodology: This was a cross-sectional study of 18 cases of unilateral nephroblastoma, carried out in the pediatric oncology unit (UOP) of the CHU Gabriel Touré from January 2015 to December 2016. Results: The mean age of the patients was 33 months old. The sex ratio was 0.63. The average consultation time was 3 months. A case of malformation syndrome (aniridia and mental retardation) had been observed. The main reason for consultation was abdominal mass (100%) associated with deterioration of general condition (44%), pain (44%) and fever (17%). Stage I accounted for 61% and stage II 39%. The postoperative histological classification made it possible to find the high-risk blastematous type (33%), the regressive type of intermediate risk (11%) and the stromal type of intermediate risk (45%). Toxicities (haematological and digestive) were minimal. The 3-year overall survival was 90%. Conclusion: This study is characterized by the predominance of stages I and II and the fairly large percentage of histology at intermediate risk. These results are above all the result of multidisciplinary collaboration.

Cancer, Child, Nephroblastoma, Diagnosis, Prognosis, Mali

Doumbia, A.K., Togo, P., Maiga, M., Cissé, M.E., Dembélé, G., Coulibaly, O., Sacko, K., Maiga, B., Konaté, D., Diarra, A., Coulibaly, Y., Diakité, F.L., Diakité, A.A., Togo, B., Traore, C.B. and Bah, A. (2021) Early Management of Nephroblas-toma: A Single-Center Study in a Sub-Saharan African Country. Open Journal of Pediatrics, 11, 797-803. https://doi.org/10.4236/ojped.2021.114074