Author(s)

Santosh Kumar Yadav^1,2

¹Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam, India.
²DMPK, Sai Life Sciences Ltd., Pune, Maharashtra, India.

Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and biological evaluation. Author’s current objective is to synthesize 8-C-Methylated homoisoflavones by the reaction of 3-C-methylated dihydrochalcones with N,N’-dimethyl (chloromethylene) ammonium chloride generated in situ from DMF and PCl₅ for one carbon extension at about room temperature. The 3-C-methylated dihydrochalcones were synthesized by the reduction of 3-C-methylated chalcones, which were prepared from 3-C-methylated acetophenones and aromatic aldehydes in the presence of base. All the synthesized novel homoisoflavones’s structures were characterized by NMR and Tandem Mass Spectrometry.

8-C-Methylated Homoisoflavones, 3-C-Methylated Dihydrochalcones, 3-C-Methylated Chalcones, 3-C-Methylated Acetophenones, Dimethylformamide, BF₃·Et₂O, PCl₅

Yadav, S. (2021) New Convenient Synthesis of 8-C-Methylated Homoisoflavones and Analysis of Their Structure by NMR and Tandem Mass Spectrometry. International Journal of Organic Chemistry, 11, 46-54. doi: 10.4236/ijoc.2021.111005.